兰州大学生命科学学院导师介绍：丁伟

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学习经历

◆2001.9-2005.6兰州大学生命科学院 生物学国家基地班学士
◆2005.9-2010.6兰州大学和中科院上海有机化学研究所联合陪养化学生物学博士

工作经历

◆2010.9-2012.5 德国saarland大学和 Helmholtz研究所抗感染saar中心药物生物技术博士后
◆2013.1至今 兰州大学生命科学院微生物所 副教授
 
教学及指导研究生情况

指导研究生2名

发表论文及专著

1. Insight into Bacterial 6-Methylsalicyclic Acid Synthase and Its Engineering to Orsellinic Acid Synthase for Novel Spirotetronates Generation.
Wei Ding, Chun Lei, Qingli He, Yurong Bi , Wen Liu.
Chemistry & Biology, 2010, 17, 495–503 （IF=6.5）
2. Biosynthesis of 3-Methoxy-5-Methyl Naphthoic Acid and Its Incorporation into the Antitumor antibiotic Azinomycin B.
Wei Ding, Wei Deng, Manchen Tang, Gongli Tang, Yurong Bi, Wen Liu.
Molecular BioSystems, 2010, 6, 1071-1081 （IF=4.5）
3. Nitric oxide mediates abscisic acid induced thermotolerance in the calluses
from two ecotypes of reed under heat stress.
Lili Song, Wei Ding, Juan Shen, Zhiguo Zhang, Yurong Bi, Lixin Zhang.
Plant Science, 2008, 175 (6): 826-832.（Co-first author）（IF=2.5）
4. Effect of abscisic acid on heat stress tolerance in the calli from two ecotypes of Phragmites communis
Wei Ding, Lili Song, Yurong Bi.
Biologia Plantarum, 2010, 54 (1–4): 607-613（IF=1.97）
5. Genetic characterization of the Saframycin A gene cluster from Streptomyces lavendulae NRRL11002 revealing a NRPS system for the characteristic bisquinone biosynthesis in an iterative manner.
Lei Li, Wei Deng, Jie Song, Wei Ding, Qunfei, Zhao, Weiwen Song, Gongli Tang, Wen Liu.
Journal of Bacteriol, 2008, 290, 251–263.
6. Characterization of the Azinomycin B Biosynthetic Gene Cluster Revealing a Different Iterative Type I Polyketide Synthase for Naphthoate Biosynthesis.
Qunfei Zhao, Qingli He, Wei Ding, Mancheng Tang, Qianjin Kang, Yi Yu, Wei Deng, Qi Zhang, Jie Fang, Gongli Tang, and Wen Liu.
Chemistry & Biology, 2008, 15, 693-705.
7. Aromatic polyketides produced by bacterial Iterative type I polyketide synthases
Qi Zhang, Bo Pang, Wei Ding, and Liu, Wen*
ACS Catal., 2013, 3 (7), pp 1439–1447
8. Nitric oxide protects against oxidative stress under heat stress in the calluses from two ecotypes of reed.
Lili Song, Wei Ding, Mingui Zhao, Baoteng Sun, Lixin Zhang.
Plant Science, 2006, 171 (4): 449-458.
9. Engineer 6-MSAS and Combinatorial synthesis NewSpirotrtronates antibiotics with improved bioactivity
Wen Liu, wei ding
(Chinese patent No. : 200910247567.8)

研究方向

微生物天然产物（抗生素）的宏基因组发掘（genome mining）， 重要生物活性抗生素的生物合成机制和新型酶催化反应机制研究 ，重要临床药物中间体的生物转化， 抗生素工业菌种的基因工程改造。