兰州大学生命科学学院导师介绍：刘恒

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学习经历

1988年至1993年在兰州医学院（现兰州大学公共卫生学院）预防医学系读本科，获学士学位。

1995年至1998年在兰州医学院（现兰州大学基础医学院）生理学研究室师从瞿颂义教授获硕士学位。

1998年至2002年在兰州大学生命科学学院细胞生物学研究所师从郑国锠院士获博士学位。

09/1998-12/2002Ph.D.LanZhou UniversityMajor in Cell Biology

09/1995-09/1998M.D. LanZhou Medical College Major in Physiology

09/1988-06/1993B.M. LanZhou Medical College Major in Preventive Medicine

工作经历

1993年至1995年在甘肃省劳动卫生与职业病防治研究所监督科（现甘肃省卫生厅卫生监督所）工作。

1999年5月至1999年12月在中科院上海植生所植物分子遗传国家重点实验室黄海课题组客座研究。

2001年9月至2002年11月在中科院上海植生所植物分子遗传国家重点实验室何玉科课题组客座研究。

2003年7月至2004年8月在美国Case Western Reserve University生化系Dr.HungYing Kao实验室从事博士后研究。

2004至2014在兰州大学生命科学学院细胞生物学研究所副教授。

2012年9月至2013年9月在美国Cornell University, Plant Biology Department, Jian Hua实验室访问学者。

2014年月至今在兰州大学生命科学学院教授

05/2014-now profesor in Life science school,Lanzhou Univesity

09/2012-09/2013Visiting Scholar in Plant Biology Department Cornell University in USA

08/2004-05/2014associate professor in Institute of Cell Biology,Life science School,Lanzhou University

07/2003-08/2004postdoc/research associate in Hungying Kao’s lab in Biochemistry Department in CWRU(CASE) in USA

01/2003-07/2003research assistant and teacher in Institute of Cell Biology in Lanzhou University

09/2001-11/2002 cooperative laboratory assistant(Yuke He’s lab) in Shanghai Institute of Plant Physiology & Ecology of China Academy of Science (CAS)

05/1999-12/1999 cooperative laboratory assistant(Hai Huang’s lab) in Shanghai Institute of Plant Physiology & Ecology of China Academy of Science (CAS)

06/1993-09/1995 occupational disease doctor and sanitary supervisor of occupational health of China in Institute of Occupational Health and Disease of GanSu Province

教学及指导研究生情况

承担本科生《细胞生物学》（省级精品课程）《生物信息学》的教学。
指导硕士研究生（毕业30人，在读9人）；协助郑国锠院士指导博士研究生（已毕业10名，在读3名）。
 
发表论文及专著

代表性论文，下划线为通讯作者（ correspondance）

2013

Overexpression of Small Heat Shock Protein LimHSP16.45 in Arabidopsis Enhances Tolerance to Abiotic Stresses. Mu C, Zhang S, Yu G, Chen N, Li X, Liu H. PLoS ONE 2013,8(12): e82264. doi:10.1371/journal.pone.0082264
 
MAIGO2 is involved in abscisic acid-mediated response to abiotic stresses and Golgi-to-ER retrograde transport. Zhao P, Liu F, Zhang B, Liu X, Wang B, Gong J, Yu G, Ma M, Lu Y, Sun J, Wang Z, Jia P, Heng Liu. Physiol Plant. 2013 Jun;148(2):246-60. doi: 10.1111/j.1399-3054.2012.01704.x.
 
Yue Niu, Yuping Wang,, Ping Li, Feng Zhang, Heng Liu, Guochang Zheng. Drought stress induces oxidative stress and the antioxidant defense system in ascorbate-deficient vtc1 mutants of Arabidopsis thaliana. Acta Physiol Plant (2013) 35:1189–1200.
 
AtSec20 is involved in osmotic stress tolerance and AtSec20 mutation unaffects the integrity of intracellular organelles and the anterograde biosynthetic trafficking. Pengshan Zhao, Fei Liu, Bing Wang, Guanzhong Yu, Pengfei Jia and Heng Liu. Acta Physiol Plant (2013) 35:1625–1632. DOI: 10.1007/s11738-012-1205-6.
 
2012

Hao Yin, Bo Yan, Jing Sun, Pengfei Jia, Zijuan Zhang, Xiaosa Yan, Juan Chai, Zhizhong Ren, Guochang Zheng, Heng Liu. Graft-union development: a delicate process that involves cell–cell communication between scion and stock for local auxin accumulation. J Exp Bot. 2012,Jun;63(11):4219-32.(IF2012: 5.364)

生长素类化合物及6-苯甲基腺嘌呤对拟南芥主根生长的抑制效应比较. 李晓峰,孟广目,梁城磊,李丹,张瑞婷,牟长军,陈倪,刘恒. 植物生理学报,2012, 48 (4): 403-407.

Analysis of Highly Expressed Genes in the Late Zygotene to Pachytene Stages of Meiotic Prophase I in David Lily. Changjun Mu, Shaobo Wang, Jiajia Pan,Shijia Zhang, Guanzhong Yu,Ni Chen, Zhaoyan Wang , Heng Liu. Russ J Plant Physiol. 2012, 59, 3, 389–397.

2011

Changjun Mu, Shaobo Wang, Shijia Zhang, Jiajia Pan, Ni Chen, Xiaofeng Li, Zhaoyan Wang ，Heng Liu. Small heat shock protein LimHSP16.45 protects pollen mother cells and tapetal cells against extreme temperatures during late zygotene to pachytene stages of meiotic prophase I in David Lily. Plant Cell Rep,2011,30:1981–1989.
 
PengShan Zhao, Fei Liu,GuoChang Zheng,Heng Liu. Group 3. late embryogenesis abundant protein in Arabidopsis:structure, regulation, and function. Acta Physiol Plant,2011,33:1063–1073.
 
Pengshan Zhao,Fei Liu,Miao Ma,Jiao Gong,Qiujun Wang,Pengfei Jia,Guochang Zheng,Heng Liu. Overexpression of AtLEA3-3 Confers Resistance to Cold Stress in Escherichia coli and Provides Enhanced Osmotic Stress Tolerance and ABA Sensitivity in Arabidopsis thaliana. Molecular Biology, 2011, 45, 5, 785–796.
 
Ping Cao, Jing Sun, Peng Zhao, Heng Liu* and Guochang Zheng. A new putative plasmodesmata-associated protein, At1g19190, in Arabidopsis. Afr. J. Biotechnol. 2011,10(76), 17409-17423.

2010：

Yuanhong Zhang, Junjie Wang, Pengfei Jia, XiaoqiangYu, Heng Liu, Xin Liu, Ning Zhao,Baibiao Huang. Two-photon fluorescence imaging of DNA in living plant turbid tissue with carbazole dicationic salt. Org Biomol Chem. 2010 Oct 21;8(20):4582-8. 
 

Zhiqiang Yan, Dawei Liang, Heng Liu, Guochang Zheng. FLC: A Key Regulator of Flowering Time in Arabidopsis. Russ J Plant Physiol2010, vol 57.2.166-174.

Xiaofeng Li, Guangmu Meng, Fei Ha, Lu Huo, Jian Wang, Shaobo Wang, Guochang Zheng, Heng Liu. Interactions of Auxin and Gibberellin in the Control of Basal Growth of Arabidopsis Rosette Leaves. Russ J Plant Physiol2010, vol 57.6.815-825.
 
Changjun Mu, Ni Chen, Xiaofeng Li, Pengfei Jia, Zhaoyan Wang, Heng Liu. F-box Protein Arabidillo-1 Promotes Lateral Root Development by Depressing the Functioning of GA3 in Arabidopsis. J.Plant Biol.(2010)53:374-380.

贾鹏飞, 刘恒, 张元红,刘鑫, 赵宁,于晓强，用于细胞核成像的2,7-BHVC双光子荧光探针 高等学校化学学报，2010， 31（6），1075-1077.
 
2009:

Ni Chen, Yan Liu, Xin Liu, Juan Chai , Zhong Hu, Heng Liu. Enhanced Tolerance to Water Deficit and Salinity Stress in Transgenic Lycium barbarum L. Plants Ectopically Expressing ATHK1, an Arabidopsis thaliana HistidineKinase Gene. Plant Mol Biol Rep.2009,27,321-333. 
 

刘鑫，刘恒，贾鹏飞，张波，王军杰，赵宁，张元红，于晓强. 一种用于细胞核成像的新型双光子荧光探针,高等学校化学学报. 2009，30，465-467.

Qiong Wu, Tao Liu, Heng Liu, Guochang Zheng. Unsaturated fatty acid: Metabolism, synthesis and gene regulation.Afr. J. Biotechnol. 2009Vol. 8 (9)1782-1785.
 
Pinxian Xi, Liang Huang, Heng Liu, Pengfei Jia, Fengjuan Chen, Min Xu, Zhengzhi Zeng. Dual-rhodamine urea derivative, a novel chemidosimeterfor Hg(II )and its application in imaging Hg(II) in living cells. J Biol Inorg Chem.2009, 14:815-819.
 
2008:

Yujian Lu, Nan Yao, Xin Liu, Ni Chen, Heng Liu. Progress in studies of Zw10, a proper chromosome segregation protein. Biol Membrany. 2008,25,2, 97-110.

2007:

Heng Liu, Guangqin Guo, Yuke He, Yuping lu, Guo-Chang Zheng. Visualization on Intercellular movement of chromatin in intact living anthers of transgenic tobacco expressing histone 2B-CFP Fusion Protein. Caryologia. 2007,60(1):1-20.
 
Changjun Mu, Heng Liu, Guo-Chang Zheng. The modification and variants of histone. Molecular Biology. 2007, 41(3):349-360.

Changjun Mu, Pengfei Jia, Zhiqiang Yan, Xin Liu, Xiaofeng Li, Heng Liu. Quercetin induces cell-cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in HepG2. Methods Find Exp Clin Pharmacol. 2007, 29(3):179-183.
 
Erin L. Reineke，Heng Liu, Minh Lam, Yu Liu and Hung-Ying Kao. Aberrant association of PML-RARalpha with co-activators contributes to its ability to regulate gene expression. J Biol Chem. 2007 , 282(25):18584-96.
 
樊玉芳,姚南,陆玉建,刘恒. EB1蛋白在调节微管动态、纺锤丝定位和染色体稳定性中的作用. 陕西师范大学学报（自然科学版）.2007,35,95-98.
 
2004:

Heng Liu, Chong-Kuang Shaw, Erin L. Reineke, Yu Liu, and Hung-Ying Kao. Retinoid X Receptorα(RXRα) Helix 12 Plays an Inhibitory Role in the Recruitment of the p160 Co-activators by Unliganded RXRα/Retinoic Acid Receptor α Heterodimers. J Biol Chem. 2004 ;279(43):45208-18.
 
研究方向

本课题组的研究方向是：植物细胞信号转导、植物功能基因组学。

.Warm-blooded animals use the thermoregulation to keep its body temperature and response to environment. Plant still has a temperature regulation system to survive in external environment. My research interesting is to understand the molecular mechnisms of the temperature regulating plant development,especially some of important cell activities,for examply,the cell cell communication between two or more plant cells,nucleo-cytoplasmic shuttling and so on.

梭梭引种肉苁蓉荒漠化防治的示范基地建设及推广：长期以来，荒漠化防治是事关我国西北，特别是甘肃省生存问题的大事。目前我们已经在甘肃民勤等地建成示范基地400亩。沿巴丹吉林沙漠从东到西，选取不同含水量的沙漠成功实施了梭梭引种肉苁蓉荒漠化防治的示范基地建设。这一应用研究的推广在荒漠化防治中具有深远而重要的意义。

欢迎有志于植物分子细胞生物学研究的青年学子报考研究生。

项目成果

目前主持国家自然科学基金面上项目一项。

已经结题的作为主持人的科研项目：

教育部科学研究重大项目一项。
国家自然科学基金面上项目一项。
教育部春晖计划一项。
甘肃省农业科技专项一项。
甘肃省农业生物技术研究与应用开发项目一项。
甘肃省科技厅成果鉴定：一种提高管花肉苁蓉愈伤组织主要药用成分的细胞工程技术。成果鉴定号：甘科鉴字2006第284号。

参与编写“细胞生物学实验（第三版）”

荣誉、获奖

教育部新世纪优秀人才支持计划（2011年）

社会工作

其它信息

2007年9月在德国zeiss公司接受激光共聚焦和双光子技术培训。

01/sept/2007-15/sept/2007 cofocal and two photon mocroscopy training in Jena,Germany