华中农业大学水产学院导师介绍：刘春生

科研项目：

（1）国家自然科学基金青年基金，21207063，建立斑马鱼胚胎胁迫通路基因分析平台研究典型有机磷阻燃剂发育毒性的分子机制，2013/01-2015/12, 在研，主持。

（2）江苏省环保科研课题，2012044，基于新型微生物污泥减量化的环境安全评价集成技术应用研究，2012/08-2014/08, 结题，主持。

（3）华中农业大学平台建设费，13203，毒理学平台建设费，2013/12-2014/12,在研，主持。

（4）华中农业大学人才建设费，14001，高层次人才科研启动经费，2013/12-2015/12，在研，主持。

（5）江苏省环境监测基金，1405，转基因斑马鱼早期生命阶段毒性测试平台构建及应用，2014/11-2015/11，在研，参加。

代表作：

(1) Jing Li, John P. Giesy, Liqin Yu, Guangyu Li*, Chunsheng Liu* (2015). Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Tetrahymena Thermophila: targeting the ribosome. Scientific Reports, 5:10562.

(2)YaoDang, John P. Giesy, Jianghua Wang*, Chunsheng Liu* (2015). Dose-dependent compensation responses of the hypothalamic-pituitary-gonadal-liver axis of zebrafish exposed to the fungicide prochloraz. Aquatic Toxicology, 160, 69-75.

(3) Liqin Yu, Zhihua Han*, Chunsheng Liu* (2015). A review on the effects of PBDEs on thyroid and reproduction systems in fish. General and Comparative Endocrinology, in press. invited review

(4) Zhihua Han, Qiangwei Wang, Jie Fu, Hongshan Chen, Ye Zhao, Bingsheng Zhou, Zhiyuan Gong, Si Wei, Jun Li, Hongling Liu, Xiaowei Zhang, Chunsheng Liu*, Hongxia Yu* (2014). Multiple bio-analytic methods to reveal possible molecular mechanisms of developmental toxicity in zebrafish embryos/larvae exposed to tris(2-butoxyethyl) phosphate. Aquatic Toxicology, 150, 175-181.

(5) Jie Fu, Changpo Zhao, Yupeng Luo, Chunsheng Liu*, George Z. Kyzas, Yin Luo, Dongye Zhao, Shuqing An, Hailiang Zhu* (2014). Heavy metals in surface sediments of the Jialu River, China: their relations to environmental factors. Journal of Hazardous Materials, 270, 102-109.

(6) Chunsheng Liu*, Hongyan Xu, Siew Hong Lam, Zhiyuan Gong* (2013). Selection of reliable biomarkers from PCR analysis using relative distance computational model: methodology and proof-of-concept study. PLOS ONE, e83954.

(7) Chunsheng Liu, Hongxia Yu, Xiaowei Zhang* (2013). Zebrafish embryos/larvae for rapid determination of effects on hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-interrenal (HPI) axis: mRNA expression. Chemosphere, 93, 2327−2332.

(8) Jie Fu, Jian Han, Bingsheng Zhou, Zhiyuan Gong, Eduarda M. Santos, Xiaojing Huo, Weiling Zheng, Hongling Liu, Hongxia Yu, Chunsheng Liu* (2013). Toxicogenomic responses of zebrafish embryos/larvae to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) reveal possible molecular mechanisms of developmental toxicity. Environmental Sciences & Technology, 47, 10574−10582.

(9) Chunsheng Liu*, Qiangwei Wang, Kang Liang,Jingfu Liu, Bingsheng Zhou, Xiaowei Zhang, Hongling Liu, John P. Giesy, Hongxia Yu* (2013). Effects of tris(1,3-dichloro-2-propyl) phosphate and triphenyl phosphate on receptor-associated mRNA expression in zebrafish embryos/larvae. Aquatic Toxicology, 128-129, 147-157.

(10) Qiangwei Wang, Kang Liang, Jingfu Liu, Lihua Yang, Yongyong Guo, Chunsheng Liu*, Bingsheng Zhou* (2013). Exposure of zebrafish embryos/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic-pituitary-thyroid axis. Aquatic Toxicology, 126, 207-213.

(11) Chunsheng Liu, Wei Yan, Bingsheng Zhou, Yongyong Guo, Hongling Liu, Hongxia Yu, John P. Giesy, Jianghua Wang, Guangyu Li*, Xiaowei Zhang* (2012). Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-Propyl-2-thiouracil in zebrafish embryos. Aquatic toxicology, 118, 108-115 .

(12) Chunsheng Liu, Xiaowei Zhang, Jun Deng, Markus Hecker, John P. Giesy, BingshengZhou* (2011). Effects of prochloraz or propylthiouracil on the cross-talk between the HPG, HPA and HPT axes in zebrafish. Environmental Sciences &Technology , 45, 769-775.

(13) Chunsheng Liu, Jun Deng, Liqin Yu, Mathan Ramesh, Bingsheng Zhou* (2010). Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 FTOH fluorotelomer alcohol. Aquatic toxicology, 96, 70-76.

(14) Chunsheng Liu, Xiaowei Zhang, Hong Chang, Paul Jones, Steve Wiseman, Jonathan Naile, Markus Hecker, John P. Giesy, Bingsheng Zhou* (2010). Effects of fluorotelomer alcohol 8:2 FTOH on steroidogenesis in H295R cells: Targeting the cAMP signaling cascade. Toxicology and Applied Pharmacology, 247, 222-228.

(15) Chunsheng Liu, Liqin Yu, Jun Deng, Paul K.S. Lam, Rudolf S.S. Wu, Bingsheng Zhou* (2009). Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic-pituitary-gonadal (HPG) axis in zebrafish. Aquatic toxicology, 93, 131-137.

(16) Chunsheng Liu, Yongbing Du, Bingsheng Zhou* (2007). Evaluation of estrogenic activities and mechanism of action of perfluorinated chemicals determined by vitellogenin induction in primary cultured tilapia hepatocytes. Aquatic Toxicology, 85, 267-277.

(17)Chunsheng Liu, Ke Yu, Xiongjie Shi, Jingxian Wang, Paul K.S. Lam, Rudolf S.S. Wu and Bingsheng Zhou* (2007).Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia (Oreochromis niloticus). Aquatic Toxicology, 82, 135-143.