华中农业大学生命科学技术学院导师介绍：孙明

导师信息来源：中国半岛真人体育 2015-07-14　相关院校：华中农业大学

姓名

孙明

性别

男

职称

教授

学位

博士

电话

027-87283455

邮箱

m98sun@mail.hzau.edu.cn

工作单位

生命科学技术学院，农业微生物学国家重点实验室

研究方向

微生物农药，芽胞杆菌分子生物学

教育经历

1992/09—1995/12,  华中农业大学土化系/生命科学技术学院，微生物专业, 博士
1988/09—1991/07,  华中农业大学土化系，微生物专业，硕士
1984/09—1988/07,  武汉大学生物系，微生物专业, 本科(学士)

主要职历

1991/09—现在,     华中农业大学土化系/生命科学技术学院微生物专业，助教，讲师, 副教授, 教授, 博士生导师
2004/05—2004/11,  香港大学生物多样性和生态学系，香港裘槎基金会(The Croucher Foundation) 访问学者
2002/07—2003/01,  美国 Cornell University微生物系，国家留学基金高级访问学者
1997/10—1998/10,  新加坡 Institute of Molecular Agrobiology, 中新合作项目访问学者
1997/06—1997/09,  加拿大University of Waterloo化工系和生物系，UNESCO-ASM资助访问学者
1994/05—1994/11,  美国The Ohio State University 生化系，WHO资助访问学者

科研成果

1) Wang P, Zhang C, Zhu Y, Deng Y, Guo S, Peng D, Ruan L, Sun M*. (2013) The resolution and regeneration of a cointegrate plasmid reveals a model for plasmid evolution mediated by conjugation and oriT site-specific recombination. Environ Microbiol, 15(12):3305-3318.

2) Zheng J, Peng D, Song X, Ruan L, Mahillon J, Sun M*. (2013) Differentiation of Bacillus anthracis, B. cereus, and B. thuringiensis on the basis of the csaB gene reflects host source. Appl Environ Microbiol, 79(12):3860-3386.

3) Luo X, Chen L, Huang Q, Zheng J, Zhou W, Peng D, Ruan L, Sun M*. (2013) Bacillus thuringiensis metalloproteinase Bmp1 functions as a nematicidal virulence factor. Appl Environ Microbiol, 79(2):460-468.

4) Zheng J, Peng D, Ruan L, Sun M*. (2013) Evolution and dynamics of megaplasmids with genome sizes larger than 100 kb in the Bacillus cereus group. BMC Evol Biol, 13:262.

5) Wang Y, Peng D, Dong Z, Zhu L, Guo S, Sun M*. (2013) Cloning and analysis of a large plasmid pBMB165 from Bacillus thuringiensis revealed a novel plasmid organization. PLoS One, 8(12):e81746.

6) Ye W, Zhu L, Liu Y, Crickmore N, Peng D, Ruan L, Sun M*. (2012) Mining new crystal protein genes from Bacillus thuringiensis on the basis of mixed plasmid-enriched genome sequencing and a computational pipeline. Appl Environ Microbiol, 78(14):4795-4801.

7) Wang F, Liu Y, Zhang F, Chai L, Ruan L, Peng D, Sun M*. (2012) Improvement of crystal solubility and increasing toxicity against Caenorhabditis elegans by Asparagine substitution in Block 3 of Bacillus thuringiensis crystal protein Cry5Ba. Appl Environ Microbiol, 78(20):7197-7204.

8) Zhang F, Peng D, Ye X, Yu Z, Hu Z, Ruan L, Sun M*. (2012) In vitro uptake of 140 kDa Bacillus thuringiensis nematicidal crystal proteins by the second stage juvenile of Meloidogyne hapla. PLoS One, 7(6):e38534.

9) Peng D, Wang F, Li N, Zhang Z, Song R. Zhu Z, Ruan L, Sun M*. (2011) Single cysteine substitution in Bacillus thuringiensis Cry7Ba1 improves the crystal solubility and produces toxicity to Plutella xylostella larvae. Environ Microbiol, 13(10):2820-2831.

10) Luo Y, Ruan L, Zhao C, Wang C, Peng D, Sun M*. (2011) Validation of the intact Zwittermicin A biosynthetic gene cluster and discovery of a complementary resistance mechanism in Bacillus thuringiensis. Antimicrob Agents Chemother, 55(9):4161-4169.

11) Peng D, Qiu D, Ruan L, Zhou C, Sun M*. (2011) Protein elicitor PemG1 from Magnaporthe grisea induces SAR in plants through the salicylic acid and Ca²⁺-related signaling pathways. Mol Plant Microbe Interact, 24(10):1239-1246.

12) Zhu Y, Ji F, Shang H, Zhu Q, Wang P, Xu C, Deng Y,Peng D, Ruan L, Sun M*. (2011) Gene clusters located on two large plasmids determine spore crystal association (SCA) in Bacillus thuringiensis subsp. finitimus strain YBT-020. PloS One, 6(11):e27164.

13) Zhong C, Peng D, Ye W, Chai L, Qi J, Yu Z, Ruan L, Sun M*. (2011) Determination of plasmid copy number reveals the total plasmid DNA amount is greater than the chromosome DNA amount in Bacillus thuringiensis YBT-1520. PLoS One, 6(1):e16025.

14) Peng D, Chai L, Wang F, Zhang F, Ruan L, Sun M*. (2011) Synergistic activity between Bacillus thuringiensis Cry6Aa and Cry55Aa toxins against Meloidogyne incognita. Microb Biotechnol, 4(6):794-798.

15) Liu X, Ruan L, Hu Z, Peng D, Cao S, Zheng J, Liu Y, Yu Z, Sun M*. (2010) Genome wide screening revealed the genetic determinants of an antibiotic insecticide in bacillus thuringiensis. J Biol Chem, 285:39191-39200.

16) Peng D, Xu X, Ruan L, Yu Z, Sun M*. (2010) Enhancing Cry1Actoxicity by expression of the Helicoverpa armigera cadherin fragment in Bacillus thuringiensis. Res Microbiol, 161:383-389.

17) Peng D, Xu X, Ye W, Yu Z, Sun M*. (2010) Helicoverpa armigera cadherin fragment enhances Cry1Acinsecticidal activity by facilitating toxin-oligomer formation. Appl Microbiol Biotechnol,85(4):1033-1040.

18) Ban H, Chai X, Lin Y, Zhou Y, Peng D, Zhou Y, Zou Y, Yu Z, Sun M*. (2009) Transgenic Amorphophallus konjac expressing synthesized acyl-homoserine lactonase (aiiA) gene exhibit enhanced resistance to soft rot disease. Plant Cell Rep, 28(12):1847-1855.

19) Fang S, Wang L, Guo W, Zhang X, Peng D, Luo C, Yu Z, Sun M*. (2009) Bacillus thuringiensis Bel protein synergizes the toxicity of Cry1Acprotein to Helicoverpa armigera larvae by degrading insect intestinal mucin. Appl Environ Microbiol, 75(16): 5237-5243.

20) Ji F, Zhu Y, Ju S, Zhang R, Yu Z, Sun M*. (2009) Promoters of crystal protein genes do not control crystal formation inside exosporium of Bacillus thurin giensis subsp. finitimus strain YBT-020. FEMS Microbiol Lett, 300(1):11-17.

21) Liu X, Peng D, Luo Y, Ruan L, Yu Z, Sun M*. (2009) Construction of an Escherichia coli to Bacillus thuringiensis shuttle vector for large DNA fragments. Appl Microbiol Biotechnol, 82(4):765-772.

22) Peng D, Luo Y, Guo S, Zeng H, Ju S, Yu Z, Sun M*. (2009) Elaboration of an electroporation protocol for larger plasmids and wild-type strains in Bacillus thuringiensis. J Appl Microbiol, 106:1849-1858.

23) Guo G, Zhou Z, Ma Q, Liu J, Zhu L, Yu Z, Sun M*. (2008) A new group of parasporal inclusions encoded by S-layer gene of Bacillus thuringiensis. FEMS Microbiol Lett, 282(1):1-7.

24) Guo S, Liu M, Peng D, Ji S, Wang P,Yu Z, Sun M*. (2008) New strategy for isolating novel nematicidal crystal protein genes from Bacillus thuringiensis strain YBT-1518. Appl Environ Microbiol, 74(22):6997-7001.

25) Liu X, Zhu S, Ye W, Ruan L, Yu Z, Zhao C, Sun M*. (2008) Genetic characterization of two putative toxin-antitoxin systems on cryptic plasmids from Bacillus thuringiensis strain YBT-1520. J Microbiol Biotechnol, 18(10):1630-1633.

26) Liu M, Li S, Hu S, Zhao C, Bi D, Sun M*. (2008) Display of avian influenza virus nucleoprotein on Bacillus thuringiensis cell surface using CTC as a fusion partner. Appl Microbiol Biotechnol, 78(4):669-676.

27) Peng D, Zhou C, Chen S, Ruan L, Yu Z, Sun M*. (2008) Toxicological safety assessment of genetically modified Bacillus thuringiensis with additional N-Acyl homoserine lactonase gene. Environ Toxicol Chem, 27(1): 173-180.

28) Song R, Peng D, Yu Z, Sun M*. (2008) Carboxy-terminal half of Cry1Ccan help vegetative insecticidal protein to form inclusion bodies in the mother cell of Bacillus thuringiensis. Appl Microbiol Biotechnol, 80: 647-654.

29) Yu Z, Bai P, Ye W, Zhang F, Ruan L, Yu Z, Sun M*. (2008) A novel negative regulatory factor for nematicidal Cry protein gene expression in Bacillus thuringiensis. J Microbiol Biotechnol, 18(6):1033-1039.

30) Yu Z, Liu B, Zou X, Yu Z, Sun M*. (2008) Establish a bioassay to assess nematicidal effect of Bacillus thuringiensis Crystalprotein against Meloidogyne hapla. Acta Phytopathologica Sinica, 38(2):219-224.

31) Zhang L, Hu C, Ye W, Zhu D, Yu Z, Zhuo R, Sun M*. (2008) The copper-resistant bacterium ACU isolated from the rhizosphere of Eichhornia crassipes (Mart.) increased the endurance of Potamogeton crispus L. to copper toxicity. J Appl Microbiol, 105:1034-1043.

32) Zhao C, Song C, Luo Y, Yu Z, Sun M*. (2008) L-2,3-Diaminopropionate: One of the building blocks for the biosynthesis of Zwittermicin A in Bacillus thuringiensis subsp. kurstaki strain YBT-1520. FEBS Lett, 582 (20): 3125-3131.

33) Zhao C, Zeng H, Yu Z, Sun M*. (2008) N-acyl homoserine lactonase promotes prevention of Erwinia virulence with Zwittermicin A-producing strain Bacillus cereus. Biotechnol Bioeng,100(3):599-603.

34) Peng D, Chen S, Ruan L, Li L, Yu Z, Sun M. (2007) Safety assessment of transgenic Bacillus thuringiensis with VIP insecticidal protein gene by feeding studies. Food Chem Toxicol, 45:1179-1185.

35) Huang J, Han D, Yu Z, Sun M. (2007) A novel cryptic plasmid pBMB175 from Bacillus thuringiensis subsp. tenebrionis YBT-1765. Arch Microbiol, 188:47-53.

36) Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z, Sun M. (2007) Identification of three Zwittermicin A biosynthesis-related genes from Bacillus thuringiensis subsp. kurstaki strain YBT-1520. Arch Microbiol, 187:313-319.

37) Zhang L, Ruan L, Hu C, Wu H, Chen S, Yu Z, Sun M. (2007) Fusion of the genes for AHL-lactonase and S-layer protein in Bacillus thuringiensis increases its ability to inhibit soft rot caused by Erwinia carotovora. Appl Microbiol Biotechnol,74:667-675.

38) Zhou Y, Ye WX, Zhou Y, Zhu CG, Sun M, Yu ZN. (2006) Ethanol tolerance, yield of melanin, swarming motility and growth are correlated with the expression levels of aiiA gene in Bacillus thuringiensis. Enzyme Microb Technol, 38:967-974.

39) Zhu CG, C. Ruan LF, Peng DH, Yu ZN, Sun M (2006) Vegetative insecticidal protein enhancing the toxicity of Bacillus thuringiensis subsp kurstaki against Spodoptera exigue. Lett Appl Microbiol, 42: 109-114.

40) Huang J, Guo S, Mahillon J, Van der Auwera GA, Wang L, Han D, Yu Z, Sun M. (2006) Molecular characterization of a DNA fragment harboring the replicon of pBMB165 from Bacillus thuringiensis subsp. tenebrionis. BMC Genomics, 7:270.

41) Zhu C, Yu Z, Sun M. (2006) Restraining Erwinia virulence by expression of N-acyl homoserine lactonase gene pro3A-aiiA in Bacillus thuringiensis subsp leesis. Biotechnol Bioeng, 95(3):526-532.

42) 孙明(主编) 基因工程(第二版), 高等教育出版社, 63万字, 2013.

备注

2000年入选教育部“跨世纪优秀人才培养计划”，2011年入选农业部农业科研杰出人才及其创新团队, 2013年入选湖北省教学名师，2002年享受国务院政府特殊津贴待遇。现任农业微生物学国家重点实验室副主任, 中国微生物学会理事兼农业微生物学专业委员会副主任、湖北省暨武汉市微生物学会常务理事兼农业微生物学专业委员会主任，第二届微生物学名词审定委员会委员，农业部肥料登记评审委员会委员，《氨基酸和生物资源》期刊主编。曾任国家自然科学基金委员会第12届专家评审组成员。曾获“湖北省技术发明一等奖”、“湖北省自然科学奖三等奖”、“教育部提名国家自然科学奖二等奖”和“武汉市科技进步奖二等奖”等奖项。