中国药科大学生命科学与技术学院研究生导师介绍：周长林

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周长林简介

1、简历

周长林，男，1964年1月生，1986、1989和1997年于华东理工大学生物工程专业分别获学士、硕士和博士学位，1999.4-2000.3年日本近畿大学药学部访问学者，2004.12-2005.11年美国ProvidenceCollege生物系博士后。现为中国药科大学生命科学与技术学院副院长、教授、博士生导师，国家药品食品监督管理局化妆品评审专家、卫生部第六届兽药评审专家，国家国际科技合作专项项目、中国博士后科学基金评审专家，担任中国微生物学会酶工程专业委员会委员、江苏省第九届生物化学和分子生物学学会常务理事,《中国药科大学学报》、《中国生化药物杂志》、《药物生物技术》、《药学与临床研究》杂志编委。2008年被评为江苏省“青蓝工程”中青年学术带头人。长期从事微生物与生化药学教学和研究工作，主要研究方向为微生物代谢调控和药物生物合成、抗感染药物药效学及其机理。主持多项国家、省部级和横向科研课题。至今发表研究论文近100篇，其中SCI收录30篇，申请多项发明专利（授权10项），主编出版教材4部。

2、研究方向

微生物代谢调控的分子机制和药物生物合成、抗感染药物药效及机理。

3、近年来发表研究论文（SCI）

(1) Yang Yang, Chao Yuan, Jie Dou, Xiaorong Han, Hui Wang, Hongqing Fang, Changlin Zhou*. Recombinant expression of glpK and glpD genes improves the accumulation of shikimic acid in E. coli grown on glycerol. World J Microbiol Biotechnol (2014) 30: 3263-3272 (IF 1.779)
(2) Yue Ding, Jie Dou, Zaijin Teng, Jie Yu, Tingting Wang, Na Lu, Hui Wang, Changlin Zhou*. Antiviral activity of baicalin against influenza A (H1N1/ H3N2) virus in cell culture and in mice and its inhibition of neuraminidase. Arch Virol (2014), 159 (12): 3269-3278 (IF 2.39)
(3) Wang Y, Wang W, Lv Y, Zheng W, Mi Z, Pei G, An X, Xu X, Han C, Liu J, Zhou C*, Tong Y*. Characterization and complete genome sequence analysis of novel bacteriophage IME-EFm1 infecting Enterococcus faecium. J Gen Virol. 2014 Nov; 95(Pt 11): 2565-75 (IF 3.183)
(4) Mengyun Ke, Hui Wang, Min Zhang, Yuwei Tian, Yizhou Wang, Bing Li, Jie Yu, Jie Dou, Tao Xi, Changlin Zhou*. The anti-lung cancer activity of SEP is mediated by the activation and cytotoxicity of NK cells via TLR2/4 in vivo. Biochemical Pharmacology, 2014, 89: 119-130 (IF 5.009)
(5) Jing Wang, Bing Li, Yang Li, Jie Dou, Qingru Hao, Yuwei Tian, Hui Wang, Changlin Zhou*. BF-30 effectively inhibits ciprofloxacin-resistant bacteria in vitro and in a rat model of vaginosis. Arch Pharm Res. 2014, 37(7): 927-936 (IF 2.046)
(6) Yuwei Tian, Hui Wang, Bing Li, Mengyun Ke, Jing Wang, Jie Dou, Changlin Zhou*. The cathelicidin-BF Lys16 mutant Cbf-K16 selectively inhibits non-small cell lung cancer proliferation in vitro. Oncol Rep. 2013; 30: 2502-2510 (IF 2.297)
(7) Hui Wang, Mengyun Ke, Yuwei Tian, Jing Wang, Bing Li, Yizhou Wang, Jie Dou, Changlin Zhou*. BF-30 selectively inhibits melanoma cell proliferation via cytoplasmic membrane permeabilization and DNA-binding in vitro and in B16F10-bearing mice. European Journal of Pharmacology. 2013; 707: 1-10 (IF 2.592)
(8) Qingru Hao, Hui Wang, Jing Wang, Jie Dou, Min Zhang, Weidong Zhoua, Changlin Zhou*. Effective antimicrobial activity of Cbf-K16 and Cbf-A7A13 against NDM-1-carrying Escherichia coli by DNA binding after penetrating the cytoplasmic membrane in vitro. J. Pept. Sci. 2013; 19: 173–180 (IF 2.071)
(9) Kai Chen, Jie Dou, Shirui Tang, Yishun Yang, Hui Wang, Hongqing Fang, Changlin Zhou*. Deletion of the aroK gene is essential for high shikimic acid accumulation through the shikimate pathway in E. coli. Bioresource Technology, 2012 May 29; 119C: 141-147 (IF 4.75)
(10) Zhenzhen Su, Jie Dou, Zhipeng Xu, Qinglong Guo, Changlin Zhou*. A novel inhibitory mechanism of baicalein on influenza A/FM1/1/47 (H1N1) virus: interference with mid-late mRNAs synthesis in cell culture. Chinese Journal of Natural Medicines. 2012, 10(6): 415-420 (SCIE)
 (11) Xitao Cao, Minghua Yang, Jie Dou, Kai Chen, Hui Wang, Tao Xi, Changlin Zhou*. Strain improvement for enhanced production of S-adenosyl-L-methionine in Saccharomyces cerevisiae based on ethionine-resistance and SAM synthetase activity. Ann Microbiol. (2012) 62:1395–1402 (IF 1.549)
(12) Mengyu Wang, Hui Wang, Ying Tang, Di Kang, Yu Gao, Mengyun Ke, Jie Dou, Tao Xi , Changlin. Zhou*. Effective inhibition of a Strongylocentrotus nudus eggs polysaccharide against hepatocellular carcinoma is mediated via immunoregulation in vivo. Immunol Lett. 2011 Dec 30; 141(1): 74-82 (IF 2.526)
(13) Hui Wang , Mengyu Wang , Jing Chen , Ying Tang, Jie Dou, Jian Yu, Tao Xi, Changlin Zhou* . A Polysaccharides from Strongylocentrotus nudus eggs (SEP) activated splenocytes proliferation in immunosuppressed mice via PI-3k/Akt signaling pathway. International Immunopharmacology, 2011, 11 (11): 1946-1953 (IF 2.376)
(14) Lili Chen, Jie Dou, Zhenzhen Su, Huimin Zhou, Hui Wang, Weidong Zhou, Qinglong Guo, Changlin Zhou*. Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Research. 2011, 91(3): 314-320 (IF 4.301)
(15) Huimin Zhou, Jie Dou, Jing Wang, Lili Chen, Hui Wang, Weidong Zhou, Yunman Li, Changlin Zhou*. The antibacterial activity of BF-30 in vitro and in infected burned rats is through interference with cytoplasmic membrane integrity. Peptides. (2011), 32(6): 1131-1138 (IF 2.434)
(16) Ren Y, Fang H, Dai H, Li S, Chen H, Zhou C, Yao X. Production of Nalpha-acetylated thymosin alpha1 in Escherichia coli. Microb Cell Fact. 2011 Apr 22; 10 (1):26 (IF 3.552)
(17) Jie Dou, Lili Chen, Ge Xu, Lei Zhang, Huimin Zhou, Hui Wang, Zhenzhen Su, Mengyun Ke, Qinglong Guo, Changlin Zhou*. Effects of Baicalein on Sendai Virus In Vivo Are Linked to Serum Baicalin and Its Inhibition of Hemagglutinin-Neuraminidase. Arch Virol (2011), 156(5):793–801（IF 2.111）

4、联系方式

中国药科大学，生命科学与技术学院，微生物学教研室；

江苏省南京市中央路童家巷24号，邮编：210009；

Tel.:025-8327-1323，Fax:025-8327-1249；

E-mail:cl_zhou@cpu.edu.cn