中国药科大学生命科学与技术学院研究生导师介绍：曹荣月

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曹荣月,硕士生导师，优秀本科生导师。中国生物化学与分子生物学会会员（S221020013M）。东南大学医学院医学遗传学专业硕士毕业，中国药科大学药理学专业博士毕业。江宁大学城巡讲讲师，在中国药科大学讲授课程为药学院各专业的生物化学与分子生物学、药学院临床药学专业的医学生物化学、中药学院的生物化学以及分子生物学、专业英语、营养学的生物化学基础等。近年来发表的各类论文60多篇，其中SCI论文30篇，其中在Journal of Immunology（影响因子6.2）、Endocrine-Related Cancer（影响因子5.8）、Vaccine（影响因子3.159）等较高影响因子杂志上发表有论文。参编教材三本，获校教学成果一等奖一项，江苏省教学成果奖一项，江苏省科技进步奖一项。主持并完成三项江苏省自然基金的项目，参与国家自然科学基金五项。申请国家专利并获多项国家专利证书，2014年9月成功转让专利一项。现在研究方向为微生物与生化药物研究与开发,重点在于抗肿瘤生物药物以及肿瘤疫苗药物的研究。

部分SCI文章：

[1]Xue JunWang & Li Jun Zhou & Xue Jiang Zhu & Kai Gu &Jie Wu & Tai Ming Li & Li Yuan & Rong Yue Cao. etection of antibodies against customized epitope: useof a coating antigen employing VEGF as fusion partner[J]. Appl Microbiol Biotechnol. 2014, 98:6659–6666

[2]X-h Sun, R-y Cao*, Y-x Wu, Y Liu, X-y Zhang. Ethanol thermal synthesis and antibacterial properties of Ag modified ZnO nanorods [J]. Materials Technology. 2014; 29( 2):105-111

[3] Jie Yang, Yanfei Xie, Huaqian Wang, Yi Yao, Jing Hou, Yanjun Ma, Qing Zhang, Yun Xing, Jie Wu, Taiming Li, Junnian Zheng, Jingjing Liu, Rongyue Cao. Administration of heat shock protein 65 inhibits murine melanoma growth in vivo [J]. Molecular Medicine Reports,2013;7(1):171-176.

[4] Yang Jie,Zhang Yankai,Wang Huaqian,Gao Zhenqiu,Wang Zeyu,Liu Bin,Zhang Xiuhua,Du Mingzhu,Huang Xiao,Xu Maolei,Wu Jie,Li Taiming,Liu Jingjing,Cao Rongyue.Vaccination with the repeat [beta]-hCG C-terminal peptide carried by heat shock protein-65 (HSP65) for inducing antitumor effects[J].Tumor Biology,2012;33(5):1777-1784.

[5] Long Jun, Lin Jie, Yuan Dongpingc, Yang Xin, Li Taiming, Cao Rongyue, Wu Jie,  Liu Jingjing.Effects of nasal immunization of multi-target preventive vaccines on atherosclerosis[J].Vaccine ,2012;30(6):1029-1037.

[6] Long Jun, Lin Jie, Yang Xin, Yuan Dongping, Wu Jie, Li Taiming, Cao Rongyue, Liu Jingjing, Nasal immunization with different forms of heat shock protein-65 reduced high-cholesterol-diet-driven rabbit atherosclerosis[J]. International Immunopharmacology,2012;375(1):172-9.

[7] Ge C, Xing Y, Wang Q, Xiao W, Lu Y, Hu X, Gao Z, Xu M, Ma Y, Cao R, Liu J.Improved efficacy of therapeutic vaccination with dendritic cells pulsed with tumor cell lysate against hepatocellular carcinoma by introduction of 2 tandem repeats of microbial HSP70 peptide epitope 407-426 and OK-432[J].Int Immunopharmacol. 2011;11(12):2200-7.

[8] Xiangbing H, Yankai Z, Ming L, Yong L, Yu Z, Huiyong Z, Yingying C, Jing H, Yun X, Liang J, Rongyue C, Jingjing L. The fusion protein of HSP65 with tandem repeats of β-hCG acting as a potent tumor vaccine in suppressing hepatocarcinoma[J]. International Immunopharmacology, 2010 ;10(2):230-238.

[9] Yong L, Huiyong Z, Jing H, Huaqian W, Xiangbing H, Yanjun M, Xiaoyu G, Li H, Yanan Y, Rongyue C, Hao F, Jingjing L, Jie W. Vaccination with a potent DNA vaccine targeting B-cell epitopes of hGRP induces prophylactic and therapeutic antitumor activity in vivo[J]. Gene Ther. 2010; 17(4):459-68.

[10] Wang XJ, Gu K, Xu JS, Li MH, Cao RY, Wu J, Li TM, Liu JJ. Immunization with a recombinant GnRH vaccine fused to heat shock protein 65 inhibits mammary tumor growth in vivo[J]. Cancer Immunol Immunother, 2010;59(12):1859-66.

[11] Jean Louis Didier MEKOO, Yanan YANG, Taiming Li, Rongyue CAO, Jingjing LIU. Molecular Cloning and Expression of a Synthetic Gene Encoding a β-glucosidase of Aspergillus Nigerin the Methylotrophic Yeast Pichia Pastoris[J]. International Journal of Biology. 2010;2(2):40-49.

[12] Yong Lu, Didier Mekoo, Ouyan Kedong, Xiangbing Hu, Yanhua Liu, Ming Lin, Liang Jin, Rongyue Cao, Taiming Li, Zhang Yankai, Hao Fan and Liu Jingjing. Strong humeral response elicited by a DNA vaccine targeting gastrin-releasing peptide with optimized adjuvant inhibits murine prostate carcinoma growth in vivo[J]. Endocrine-Related Cancer, 2009;DOI: 10.1677/ERC-09-0058.

[13] Yong Lu, Zhang Huiyong, Fang Jing, Wang Huaqian, You Kejun, Yang Yanan, Liu Suli, Wang Xuejun, Meng Yuhan, Cao Rongyue, Fan Hao, Li Taiming, Liu Jingjing.Study on preparation and unique properties of a novel insulin analogue with N-terminal Arg-4, Pro-3, Lys-2, and Pro-1extension at insulin B-chain[J]. Regulatory Peptides, Oct 2009; 157(1-3): 92-98.

[14] Yong Lu, Kedong Ouyang, Guojun Wu, Jing Fang, Huiyong Zhang, Yanhua Liu, Yingying Chen, Ming Lin, Huaqian Wang, Liang Jin, Rongyue Cao, Rouel S. Roque, Li Zong, Jingjing Liu, and Taiming Li.Specific antibodies elicited by a novel DNA vaccine targeting gastrin-releasing peptide inhibit murine melanoma growth in vivo[J]. Clin Vaccine Immunol,2009; 16(7):1033-1039.

[15] Yong Lu, Kedong Ouyang, Jing Fang, Huiyong Zhang, Guojun Wu, Yanjun Ma, Yu Zhang, Xiangbing Hu, Liang Jin, Rongyue Cao, Hao Fan, Taiming Li, Jingjing Liu.Improved efficacy of DNA vaccination against prostate carcinoma by boosting with recombinant protein vaccine and by introduction of a novel adjuvant epitope[J]. Vaccine, 2009; 27(39): 5411-8.

[16] Xiong Qiyan, Jin Liang, Li Jianping, Fan Hao, Cao Rongyue, Wu Jie, Li Taiming and Liu Jingjing. A Th2 immune shift to heat shock protein 65 fails to arrest atherosclerosis: Proatherogenic role of Th2-deviated autoantibodies[J]. Autoimmunity, 2009; 42(6): 475–483.

[17] Jiao Feng, Yanhua Liu, Yun Xing, Huaqian Wang, Taiming Li, Jingjing Liu, Hao Fan, Rongyue Cao. A novel human parathyroid hormone (1-34) analog for the treatment of Osteoporosis.[J]Peptides, 2009; 30(6):1173-80.

[18] Huaqian Wang, Jie Yang, Liang Jin, Jiao Feng, Yong Lu, Yunxiao Sun, Taiming Li, Rongyue Cao, Jie Wu, Hao Fan, and Jingjing Liu*. Immunotherapy of Autoimmune Diabetes by Nasal Administration of Tandem Glutamic Acid Decarboxylase 65 Peptides [J]. Immunological Investigations.2009;38(8):690-703.

[19] Xue Jun Wang*, Kai Gu, Qi Yan Xiong, Liang Shen, Rong Yue Cao, Ming Hui Li, Tai Ming Li, Jie Wu*, Jing Jing Liu. A novel virus-like particle based on hepatitis B core antigen and substrate-binding domain of bacterial molecular chaperone DnaK [J]. Vaccine. 2009; 27(52):7377-7384.

[20] Yunxiao Sun，Zhufang Li，Xin Yang; Jun Long; Qiyan Xiong，Gaofu Qi，Rongyue Cao, Jie Wu, Jingjing Liu, Hao Fan, Taiming Li. Construction, Expression,Purification and Immunology Effect of an Antiatherosclerosis Chimeric Enzyme Vaccine in Escherichia coli[J]. Protein & Peptide Letters, 2008;15:745-52.

[21] Wu Guojun, Guo Wei, Ouyan Kedong, He Yi, Xie Yanfei, Chen Qingmei, Zhang Yankai, Wu Jie, Fan Hao, Li Taiming, Liu Jingjing and Cao Rongyue. Novel vaccine targeting gastrin-releasing peptide: Efficient inhibition of breast cancer growth in vivo [J].Endocr Relat Cancer, 2008; 15(1):149-59.

[22] Liang Jin, Aihua Zhu, Yu Wang, Qingmei Chen, Qiyan Xiong, Jianping Li, Yunxiao Sun, Taiming Li, Rongyue Cao, Jie Wu and Jingjing Liu. A Th1-recognized peptide P277, when tandemly repeated, enhances a Th2 immune response toward effective vaccines against autoimmune diabetes in nonobese diabetic mice [J]. J Immunol, 2008; 180(1):58-63.

[23] Liang Jin, Yu Wang, Qiyan Xiong, Qingmei Chen, Jianping Li, Aihua Zhu, Rongyue Cao, Jie Wu, Jingjing Liu. Long-lasting specific antibodies against P277 induced by mucosal administration of P277 repeat sequences carried by Hsp65 in the absence of adjuvants [J]. Vaccine, 2007; 25(11):2043-50.

[24] Zhang Yankai, Yan Rong, He Yi, Liu Wentao, Cao Rongyue, Yan Ming, Li Taiming, Liu Jingjing, Wu Jie. Ten tandem repeats of beta-hCG 109-118 enhance immunogenicity and anti-tumor effects of beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65[J]. Biochem Biophys Res Commun, 2006; 345(4):1365-71.

[25] Dan Mao, Gu Kai, Qi Gaofu, Zhu Zheng, Zhong Li, Wu Jie, Liu Jingjing, Cao Rongyue. Intramuscular immunization with a DNA vaccine encoding a 26-amino acid CETP epitope displayed by HBc protein and containing CpG DNA inhibits atherosclerosis in a rabbit model of atherosclerosis[J].Vaccine, 2006; 24(23):4942-50.

[26] Gaofu Q, Rongyue C, Dan M, Xiuyun Z, Xuejun W, Jie W, Jingjing L.Asparaginase display of human cholesteryl ester transfer protein (CETP) B cell epitopes for inducing high titers of anti-CETP antibodies in vivo[J].Protein Pept Lett, 2006; 13(2):149-54.

[27] He Yi, Yan Rong, Zhang Yankai, Liu Wentao, Zhou Hongxia, Wu Jie, Cao Rongyue, Li Taiming, Liu Jingjing. Improved efficacy of DNA vaccination against breast cancer by boosting with the repeat beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65 [J]. Vaccine, 2006; 24(14):2575-84.

[28] Xu Jinshu, Liu Jingjing, Peng Duan, Zhu Zheng, Ming Ding, Wu Jie, Cao Rongyue, Hu Zhuoyi, Rouel S. Roque . A synthetic gonadotropin-releasing hormone (GnRH) vaccine for control of fertility and hormone dependent diseases without any adjuvant[J].Vaccine, 2005; 23(40):4834-43.

[29] Gaofu Q, Jie L, Rongyue C, Xin Y, Dan M, Jie W, Xiangchun S, Qunwei X, Roque RS, Xiuyun Z, Jingjing L. Asparagines display of polypeptides in the periplasm of Escherichia coli: Potential rapid pepscan technique for antigen epitope mapping [J]. J Immunol Methods, 2005; 299(1-2):9-19.

[30] Xu Jinshu, Liu Jingjing, Peng Duan, Zhu Zheng, Ming Ding, Wu Jie, Cao Rongyue, Hu Zhuoyi. The immunogenicity of recombinant and dimeric gonadotrophin-releasing hormone vaccines incorporating a T-helper epitope and GnRH or repeated GnRH units [J].J Immunol Methods, 2004; 289(1-2):111-22.

获得的部分国家专利：

（1）能通过免疫防治Ⅰ型糖尿病的重组蛋白和重组基因

（2）HSP65重组蛋白质的制备及用途

（3）一种抗动脉粥样硬化的表位组合物、其制备方法及用途

（4）一种免佐剂具有防治Ⅰ型糖尿病作用的免疫调节剂

（5）人胰岛素类似物的制备方法及用途

（6）一种能串联表达和同步酸水解释放的人甲状旁腺素1-34肽类似物及其制备方法和应用

（7）一种新型血管内皮细胞疫苗及其制备方法

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