中国药科大学中药学院研究生导师介绍：王小兵

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王小兵，男，博士，副教授，硕士研究生导师，研究领域为天然活性成分研究与开发。

2001年毕业于汉中师范学院，获化学教育专业学士学位；2005年毕业于陕西师范大学，获有机化学专业硕士学位；2008年毕业于中国药科大学，获药物化学专业博士学位。2008年7月留校天然药物化学教研室工作，2011年6月晋升为副教授。2015年作为访问学者，在The Scripps Research Institute的Jin-Quan Yu教授课题组从事有机合成中的碳氢活化和天然产物合成研究工作。现主持国家自然科学基金面上项目和江苏省自然科学基金青年项目各一项，参与多项国家和省部级基金项目。

研究方向：

1.基于天然产物的合理药物设计与研究；
2.天然产物结构修饰与全合成；
3.天然产物生物转化研究。

主持的基金项目：

1.国家自然科学基金面上项目，基于天然产物“优势结构”和药物“活性片段”具有均衡活性的多靶点阿尔茨海默病药物分子研究，编号：81573313,2016~2019.
2.江苏省自然科学基金青年项目，若干常见中草药活性成分的酶促生物转化研究，编号：BK20130664,2013~2016.

近三年主要论文：

1.Sai-Sai Xie, Xiaobing Wang, Neng Jiang, Wenying Yu, Kelvin D. G. Wang, Jin-Shuai Lan, Zhong-Rui Li, Ling-Yi Kong*. Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease. European Journal of Medicinal Chemistry, 2015, 95, 153-165.
 2.Neng Jiang, Xiao-Bing Wang, Zhong-Rui Li, Su-Yi Li, Sai-Sai Xie, Ming Huang, Ling-Yi Kong*. Design of a structural framework with potential use to develop balanced multifunctional agents against Alzheimer's disease. RSC Advances, 2015, 5, 14242-14255.
3.Jin-Shuai Lan, Sai-Sai Xie, Ming Huang, Ya-Jian Hu, Ling-Yi Kong*, Xiao-Bing Wang*. Chromanones: selective and reversible monoamine oxidase B inhibitors with nanomolar potency. Medchemcomm, 2015, 6, 1293-1302.
4.Weisi Xiong, Xiaobing Wang, Lingyi Kong*. Design and application of a biphasic system that enhances productivity of Daucus carota-catalyzed asymmetric reduction. Biotechnology Letters, 2015, 37, 1703-1709.
5.Ming Huang, Sai-Sai Xie, Neng Jiang, Jin-Shuai Lan, Ling-Yi Kong, Xiao-Bing Wang*. Multifunctional coumarin derivatives: Monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 508-513.
6.Sai-Sai Xie1, Jin-Shuai Lan1, Xiao-Bing Wang, Neng Jiang, Ge Dong, Zhong-Rui Li, Kelvin D. G. Wang, Ping-Ping Guo, Ling-Yi Kong*. Multifunctional tacrine–trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties. European Journal of Medicinal Chemistry, 2015, 93, 42-50.
7.Zhi-Min Wang, Sai-Sai Xie, Xue-Mei Li, Jia-Jia Wu, Xiao-Bing Wang*, Ling-Yi Kong*. Multifunctional 3-Schiff base-4-hydroxycoumarin derivatives with monoamine oxidase inhibition, anti-β-amyloid aggregation, metal chelation, antioxidant and neuroprotection properties against Alzheimer's disease. RSC Advances, 2015, 5, 70395-70409.
8.Xiao-Bing Wang1, Chang-Shui Yang1, Chao Zhang, Jun Luo, Ming-Hua Yang, Jian-Guang Luo, Wen-Ying Yu, Ling-Yi Kong*. Ten new calyxins from Alpinia katsumadai: a systematically studies on the stereochemistry of calyxins. Tetrahedron, 2014, 70, 8714-8722.
9.Su-Yi Li, Xiao-Bing Wang, Neng Jiang, Ling-Yi Kong*. Synthesis of (E)-1,4-Enediones from α-halo ketones through a sodium sulfinate mediated reaction. European Journal of Organic Chemistry. 2014, 8035-8039.
10.Li Su-Yi, Jiang Neng, Xie Sai-Sai, Wang Kelvin D. G., Wang Xiao-Bing*, Kong Ling-Yi*. Design, synthesis and evaluation of novel tacrine rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease. Organic & Biomolecular Chemistry 2014, 12, 801-814.
11.He Ye, Wang Xiao-Bing, Fan Bo-Yi, Kong Ling-Yi. Honokiol trimers and dimers via biotransformation catalyzed by Momordica charantia peroxidase: Novel and potent alpha-glucosidase inhibitors. Bioorganic & Medicinal Chemistry 2014, 22, 762-771.
12.Li Su-Yi, Wang Xiao-Bing, Kong Ling-Yi. Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease. European Journal of Medicinal Chemistry 2014, 71, 36-45.
13.Xu Zi-Chen, Wang Xiao-Bing, Yu Wen-Ying, Xie Sai-Sai, Li Su-Yi, Kong Ling-Yi. Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters 2014, 24, 2368-2373.
14.Xie Sai-Sai, Wang Xiao-Bing*, Li Jiang-Yan, Yang Lei, Kong Ling-Yi*. Design, synthesis and evaluation of novel tacrine coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease. European Journal of Medicinal Chemistry 2013, 64, 540-553.
15.Xie Sai-Sai, Wang Xiao-Bing*, Li Jiang-Yan, Kong Ling-Yi*. Design, Synthesis and Biological Evaluation of Novel 7-Mercaptocoumarin Derivatives as alpha(1)-Adrenoceptor Antagonists. Chemical & Pharmaceutical Bulletin 2013, 61, 16-24.
16.Wang Xiao-Bing1, Zhang Yao1, Wang Jun-Song, Gu Yu-Cheng, Kong Ling-Yi. Novel ring A rearranged isomers with gamma-lactone from the fruits of Aphanamixis grandifolia. Tetrahedron Letters 2013, 54, 6023-6028.
17.Li Su-Yi, Wang Xiao-Bing, Xie Sai-Sai, Jiang Neng, Wang Kelvin D. G., Yao He-Quan, Sun Hong-Bin, Kong Ling-Yi. Multifunctional tacrine flavonoid hybrids with cholinergic, beta-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 2013, 69, 632-646.
18.Li Ren-Shi, Wang Xiao-Bing, Hu Xiao-Jun, Kong Ling-Yi. Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters 2013, 23, 2636-2641.
19.Hu Xiao-Jun, Wang Xiao-Bing, Kong Ling-Yi. alpha-Glucosidase Inhibitors via Green Pathway: Biotransformation for Bicoumarins Catalyzed by Momordica charantia Peroxidase. Journal of Agricultural and Food Chemistry 2013, 61, 1501-1508.
20.Bao Feng-Zu, Wang Xiao-Bing, Kong Ling-Yi. Pyrrolidine catalyzed novel domino reaction for the synthesis of polysubstituted 4-oxocyclohexanecarbaldehyde derivatives. Tetrahedron Letters 2013, 54, 1405-1408.

联系方式：

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