中国药科大学药学院研究生导师介绍：杨劲

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杨劲，中国药科大学药代中心，教授，博士。

1993年毕业留校后一直从事药代动力学研究和教学工作20余年，期间在国家药品审评中心外聘工作近一年。现为国家药品审评专家，江苏省药品审评专家，中国定量药理药理学会委员。

1、招生方向：

药代动力学；

2、研究特色

数学建模与仿真。应用于创新药物的早期临床探索研究，儿童给药方案探索研究，生物类似物评价研究，已上市药物的个体化给药研究。

3、科研成果：

评估创新药物20余个，其中有多个已经获得上市许可。

发表SCI论文20余篇，影响因子大于50。发表新药审评技术论文多篇。发表中文核心杂志论文50余篇。

主持并承担多项国家自然科学基金、国家重大新药创制专项。近几年科研经费累积超过500万元。

4、联系方式

cpu_yj@163.com

5、近几年发表代表性论文：

1)Fan G, Cao Y, Yang J(Correspondence Author). In vitro inhibition and induction of human cytochrome P450 enzymes by SIPI5357, a potential antidepressant. Biopharm Drug Dispos. 2015 Mar 16. doi: 10.1002/bdd.1947
2)Jing Z, Kuang L, Liu N, Yang J(Correspondence Author). LC-MS/MS for the simultaneous determination of polar endogenous ADMA and CML in plasma and urine from diabetics. Bioanalysis. 2015 May;7(10):1261-71. doi: 10.4155/bio.15.58.
3)Xu R, Liu X, Yang J(Correspondence Author). A semi-physiologically based pharmacokinetic pharmacodynamic model for glycyrrhizin-induced pseudoaldosteronism and prediction of the dose limit causing hypokalemia in a virtual elderly population. PLoS One. 2014 Dec 2;9(12): e114049. doi: 10.1371/journal.pone.0114049. eCollection 2014
4)Biao Yu, Pengcheng Ma, Linwen Yuan, Dingding Chen, and Jin Yang∗(Correspondence Author) Evaluation of change in the skin concentration of tazarotene and betamethasone dipropionate based on drug–drug interaction for transdermal drug delivery in miniature pig. Xenobiotica. 2014 Nov 20:1-5.
5)Xu R, Wang Q, Zhang J, Zang M, Liu X, Yang J(Correspondence Author). Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat. Xenobiotica. 2014 Jun;44(6):541-6.
6)Min Zang, Xiaoqiang Liu, Lin Chen, Qingqing Xiao, Linwen Yuan, Jin Yang∗(Correspondence Author)  Determination of BmKCT-13, a chlorotoxin-like peptide, in rat plasma by LC–MS/MS: Application to a preclinical pharmacokinetic study Journal of Chromatography B, 947–948 (2014) 125– 131
7)Liqing Kuang, Zhiqiang Jing, Jing Wang, Liyuan Ma, Xiaoqiang Liu, Jin Yang (Correspondence Author) Quantitative determination of ε-N-Carboxymethyl-L-lysine in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry. Journal of Pharmaceutical and Biomedical Analysis(IF=2.97) Journal of Pharmaceutical and Biomedical Analysis 90 (2014) 1–6
8)Shuming LI, Xiangyang WANG, Wei LI, Yang CHU. Jiahua GUO, Xiaohui MA, Jin YANG (Correspondence Author) Characterization of Metabolites in Rat after Administration of Danshensu by Liquid Chromatography-tandem Mass Spectrometry Lat. Am. J. Pharm. 2013:32 (4): 582-6
9)Yuan Lu • Jinbo Yang • Haiyan Zhang • Jin Yang. (Correspondence Author) Prediction of Warfarin Maintenance Dose in Han Chinese Patients Using a Mechanistic Model Based on Genetic and Non-Genetic Factors. Clinical Pharmacokinetics(IF=5.40). (2013) 52:567–581
10)R. Xu, Q. Xiao, Y. Cao, J.Yang(Correspondence Author) Comparison of the Exposure of Glycyrrhizin and its Metabolites and the Pseudoaldosteronism after Intravenous Administration of Alpha- and Beta-glycyrrhizin in Rat. Drug Res (Stuttg). 2013 Jul 17
11)Xu R, Zhang X, Yang J(Correspondence Author), Liu X, Davey AK, Wang J. Effects of glycyrrhizin on biliary transport and hepatic levels of glutathione in rats. Biopharm Drug Dispos(IF=2.07). 2012 Apr 17. doi: 10.1002/bdd.1789.
12)Min Zhang, Jin Yang(Correspondence Author), Lei Tao, Lingjun Li, Pengcheng Ma, and John Paul Fawcett, Acarbose Bioequivalence: Exploration of New Pharmacodynamic Parameters AAPS J(IF=5.09). 2012 Jun;14(2):345-51.
13)Feng-Juan Zhao, Hong Tang, Qing-Hua Zhang, Jin Yang, (Correspondence Author), Andrew K., Daveyc, Ji-ping Wang. Salting-out homogeneous liquid–liquid extraction approach applied in sample pre-processing for the quantitative determination of entecavir in human plasma by LC–MS Journal of Chromatography B(IF=2.89), 881–882 (2012) 119– 125
14)Guo-fu LI, Kun WANG, Rui CHEN, Hao-ru ZHAO, Jin YANG, Qing-shan ZHENG, Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal  function using whole-body physiologically based pharmacokinetic modeling. Acta Pharmacologica Sinica (2012) 33: 1359–1371
15)Chen Yanxiao Xu Ruijuan Yang Jin(Correspondence Author) Organic anion and cation transporters are possibly involved in renal excretion of entecavir in rats Life Sciences 89 (2011) (IF=2.56)1–6
16)Xiong Yu ; Yang yuqing ; Yang jin, Dr.; chai hong yan; Li ying; Yang Jing , Dr. Tectoridin, an isoflavone glycoside from the flower of Pueraria lobata, prevents acute ethanolinduced liver steatosis in mice， Toxicology. 2010 Sep 30;276(1):64-72.
17)Qing-Hua Zhang, Jin Yang(Correspondence Author) Food effect on the pharmacokinetics of entecavir from dispersible tablets following oral administration in healthy Chinese volunteers  Arzneimittelforschung 2010;60(10):640–644
18)L. Chen, J. Yang(Correspondence Author), A. K. Davey, Y.-X. Chen, J.-P. Wang, and X.-Q. Liu Efects of diammonium glycyrrhizinate on the pharmacokinetics of aconitine in rats and the potential mechanism Xenobiotica(IF=1.918), 2009; 39(12): 955–963
19)Jin Yang, Ying He Pharmacokinetic Properties of S-adenosylmethionine after Oral and intravenous administration of its Tosylate disulfate salt: a Multiple-dose, Open-Label, Parallel-Group study in Healthy Chinese volunteers Clinical Therapeutics Volume 31, Number 2, 2009 (IF=3.261)：311-320
20)Jin Yang, Liang Zhou, JipingWang, GuangjiWang, Andrew K Davey The Disposition of Diammonium Glycyrrhizinate and Glycyrrhetinic Acid in the Isolated Perfused Rat Intestine and Liver   Planta Medica 2008; 74: 1351–1356
21)袁淋文杨劲（通讯作者）Beagel犬药动学研究在缓释制剂评价体系中的作用比较.中国新药杂志2015年第24卷第10期:1134-1140
22)赵明，杨劲（通讯作者），魏敏吉置信区间法用于线性药代动力学特征评价.中国临床药理学杂志2015年2月：238-240
23)赵明，谢松梅，杨劲（通讯作者），魏敏吉.关于生物等效性试验中血药峰浓度等效界值的思考中国临床药理学杂志2014年10月：970-973
24)陈晓媛杨劲关于甲磺酸伊马替尼口服制剂生物等效性试验设计的几点考虑中国临床药理学杂志2014年9月：840-843
25)肖青青赵凤娟杨劲（通讯作者）王友群药物分布容积的预测方法中国药科大学学报2013年第03
26)何清杨劲（通讯作者）；数字胃肠道模型的建立及在硝苯地平缓释片人体吸收预测中的应用中国药科大学学报2012(01):85-91.
27)陈春，林志强，杨劲(通讯作者)模型设计在制剂研发及生产过程质量控制中的应用?《药学进展》2011年第35卷第7期289-296
28)尹雪芬林志强杨劲(通讯作者)基于转运蛋白的代谢性数字肝生理模型预测普伐他汀、匹伐他汀与环孢素的药代动力学相互作用药学学报ActaPharmaceuticaSinica2011,46(9):1108−1116
29)黎国富,杨劲(通讯作者),华小懿,陈蕊,赵浩如Ussingchamber模型研究甘草酸二铵经大鼠肠黏膜的转运特征中国中药杂志2010;35(17);p2261-2266
30)黎国富杨劲(通讯作者)张雪莹赵浩如基于胃肠道生理模型的口服药物吸收预测中国临床药理学与治疗学2010Jun;15(6):656–662
31)张雪莹,杨劲(通讯作者)谷胱甘肽的肝脏转运及其在胆汁淤积中的作用药学学报2009,44(4):1-6
32)汪音杨劲(通讯作者)傅继华刘晓东王广基基于体外模型数据模拟和预测人体内群体药代参数中国临床药理学与治疗学2008年13卷5期：545-551
33)苏笠杨劲(通讯作者)化合物脂水分配系数计算软件及比较研究中国药科大学学报2008，39（2）：178~182
34)周亮杨劲(通讯作者)，张雪莹，柳晓泉，王广基磷脂对甘草酸二铵小肠吸收的影响药学学报2008年vol.43No.171~75