中国药科大学药学院研究生导师介绍：宋瑞

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宋瑞，女，1983年11月生，博士，副教授。2005年毕业于中国药科大学中药学专业，获学士学位，2010年获本校药物分析博士学位并留校任教。

主持国家自然科学基金（81403314）、江苏省自然科学基金(BK2012349)、中央高校基本科研培育项目（JKPZ2013008）。作为主要成员参加完成国家自然科学基金（30672587、30873439）、江苏省基础研究计划（BK2006153）、国家中医药局中医药行业科研专项（200707008）等10余项国家及省部级科研项目。

研究方向：以现代色谱、光谱及其联用技术为依托，开展基于多层次代谢分析的中药配伍、炮制、中西药联用减毒增效机理研究。

联系方式：songrui@cpu.edu.cn

研究成果：2005年至今共发表相关研究领域学术论文21篇，第一作者及通讯作者论文8篇，其中SCI论文7篇。

[1] Wang M, Fu J, Lv M, Tian Y, Xu F, Song R*, Zhang Z*.Effect of wine processing and acute blood stasis on the serum pharmacochemistry of rhubarb: A possible explanation for processing mechanism. Journal of Separation Science. 2014 Jun 30. doi: 10.1002/jssc.201400473.  IF: 2.594
[2] Rui Song, Ying Cheng, Yuan Tian, Zunjian Zhang*. A validated solid−phase extraction HPLC method for the simultaneous determination of gallic acid, catechin and epicatechin in rhubarb decoction. Chinese Journal of Natural Medicines, 10(4): 0275-0278, 2012
[3] Rui Song, Lei Xu, Fengguo Xu, Hanjuan Dong, Yuan Tian, Zunjian Zhang*. Metabolic analysis of rhubarb extract by rat intestinal bacteria using liquid chromatograpy-tandem mass spectrometry. Biomedical Chromatography, 25(3): 417-426, 2011. IF: 1.966
[4] Rui Song, Lei Xu, Fengguo Xu, Zhe Li, Hanjuan Dong, Yuan Tian, Zunjian Zhang*. In vivo metabolism study of rhubarb decoction in rat using high-performance liquid chromatography with UV photodiode- and mass spectrometric detection: a strategy for systematic analysis of metabolites from traditional Chinese medicines in biological samples. Journal of Chromatography A, 1217 (45): 7144-7152, 2010. IF: 4.194
[5] Rui Song, Lei Xu, Zunjian Zhang*, Yuan Tian, Fengguo Xu, Hanjuan Dong. Validated method for determination of gallic acid in rat plasma by liquid chromatography/tandem mass spectrometry. Chromatographia, 71(11/12): 1107-1111, 2010.IF: 1.075
[6] Rui Song, Fengguo Xu , Zunjian Zhang *, Ying Liu , Haijuan Dong, Yuan Tian. Structural elucidation of in vitro metabolites of Emodin by liquid chromatography–tandem mass spectrometry. Biomedical Chromatography, 2008, 22(11):1230-1236. IF: 1.592
[7] Rui Song, Hui Lin, Zunjian Zhang*, Zhe Li, Lei Xu, Haijuan Dong, Yuan Tian. Profiling the metabolic difference of anthraquinone derivatives using liquid chromatography/tandem mass spectrometry with data-dependent acquisition. Rapid Communications in Mass Spectrometry, 2009, 23(4):537-547.IF: 2.695