中国药科大学药学院研究生导师介绍：冯芳

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冯芳,药物分析学博士，教授、博士生导师；教育部药物质量与安全预警重点实验室学术带头人。2000－2001年日本歧阜药科大学药学部高级访问学者。

研究方向药物质量研究与评价

研究内容药物质量分析方法建立研究、药物体内过程分析研究、手性药物拆分及体内立体选择性药代动力学研究、中药（复方）药效物质基础研究。

学术兼职国家药典委员会委员、国家兽药典委员会委员、国家药监局保健食品安全和技术规范专家委员会委员；国家科学技术奖励评审专家；国家药监局保健食品、化妆品、兽药评审专家；国家科技专家库在库专家；教育部高校同行评议专家；江苏省新药及保健食品审评专家。《药物分析杂志》、《中国药科大学学报》编委。

人才计划及主要荣誉江苏省“333高层次人才培养工程”首批中青年科学技术带头人；青蓝工程江苏省中青年学术带头人；“十五”国家级重点教材《药物分析》编委、省一类精品课程主要成员；《有机光谱分析》（副主编）获国家医药管理局科技进步三等奖；江苏省优秀研究生课程《药物光谱分析选论》负责人；2007、2009、2010年江苏省优秀研究生论文导师，2010年、2012年圣和研究生创新成果二等奖导师。

近年来科研工作：

1．国家自然科学基金项目负责人。

2．江苏省科技厅科技支撑计划项目负责人。

3．科技部重大新药创制项目子课题负责人。

4．企业委托新药质量研究、体内过程分析研究、代谢产物分析研究等项目负责人。

近年来代表性论文、论著：

1.An untargeted metabolomics-driven approach based on LC–TOF/MS and LC–MS/MS for the screening of xenobiotics and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma. Journal of Pharmaceutical and Biomedical Analysis. 2015,115: 315–322 .

2.An effective integrated method for comprehensive identification of eighty-five compounds in Zhi-Zi-Da-Huang decoction by HPLC-DAD-ESI-MS (TOF) and HPLC-DAD-ESI-MS/MS (QqQ) without the help of reference standards. Analytical method. 2014, 6:4312-4327.

3.Network Pharmacology-Based Antioxidant Effect Study of Zhi-Zi-Da-Huang Decoction for Alcoholic Liver Disease. Evidence-Based Complementary and Alternative Medicine. 2015, 1- 6.

4.Optimization of the separation and determination of nitidine and chelerythrine in zanthoxylum nitidum by high-performance liquid chromatography with fluorescence detection. J Chromatogr Sci. 2014 , 52(2):164-168.

5.Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: restoration of monoamine neurotransmitters in discrete brain regions. Pharm Biol. 2013, 51(2):213-20.

6.A  highly sensitive nonenzymatic glucose sensor based on CuO nanowires. Microchim Acta. 2012, 176:411-417.

7.Pharmacokinetics of Geniposide in Zhi-Zi-Hou-Pu Decoction and in Different Combinations of its Constituent Herbs. Phytotherapy Research. 2012, 26: 67-72

8.Pyrosequencing on nicked dsDNA generated by nicking endonucleases. Analytical Chemistry. 2010, 82(5):2074-81.

9.Determination of selected elements in aqueous extractions of a traditional Chinese medicine formula by ICP-MS and FAAS: evaluation of formula rationality. Analytical Letters, 2010, 43: 983-992.

10.Identification of components in Zhi-Zi-Da-Huang decoction by HPLC coupled with electrospray ionization tandem mass spectrometry, photodiode and fluorescence detectors. Journal of Pharmaceutical and Biomedical Analysis,.2009, 49, 1157-1165.

11.Evaluation of hepatoprotective effect of Zhi-Zi-Da-Huang decoction and its two fractions against acute alcohol-induced liver injury in rats. Journal of Ethnophamacology. 2009, 126, 273-279.

12.Influences of urinary pH on the pharmacokinetics of three amphetamine-type stimulants using a new high-performance liquid chromatographic method. Journal of Pharmaceutical Science. 2009, 98(2):728-38.

13.Development of a new pre-derivatization LC method for analysis of branched-chain and aromatic amino acids in rat plasma and to monitor their dynamic variation as a result of acute hepatic injury. Chromatographia, 2009, 70, 57-65.

14.主编《药物分析》，东南大学出版社，2011年。

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