北京大学

周田彦博士副教授硕士生导师

电话/传真：(10)-82801717

电子信箱：tianyanzhou@bjmu.edu.cn

简历

分别于1992 年、1998 年在北京医科大学药学院获得学士和硕士学位，98年留校至今一直在北京大学药学院药剂教研室工作，并于2006 年取得药剂学博士学位。曾到香港理工大学（2002-2004）和美国奥克拉荷马州立大学（2007-2008）作访问研究。主持了北京大学药学院青年启动基金，留学回国人员启动基金，国家自然科学基金面上项目，是北京大学创新药物平台代谢子平台的主要成员之一。近年来获得的奖励主要包括北京大学医学部优秀青年学者（2010），北京大学医学部教学优秀奖（2010），北京大学第十届青年教师教学演示（医科类）竞赛三等奖（2010），教育部“高等学校科学技术奖”自然科学二等奖（2006）等。担任《中国药学杂志》、《中国药学》英文版、《Chinese Journal of Natural Medicine》 等学术期刊的评审，在国内外发表论文30余篇，编写教材与专著6部。主讲本科生《药剂学》、 《生物药剂学与药物动力学》以及研究生《群体药物动力学以及药物动力学/药效动力学模型化与仿真》等课程。

研究领域与兴趣

基于机制的药物动力学/药效动力学链式模型

药物代谢酶的调控机理及其应用

发表论文

1. Zhou,Tianyan; Chen, Yue; Huang, Chaoqun; Chen, Guangping. Caffeine induction of sulfotransferases in rat liver and intestine. Journal of Applied Toxicology, (2011)，accepted

2. Shang, Dewei; Wang, Xipei; Zhao, Xiutai; Huang, Fengming; Tian, Ganzhong; Lu, Wei* and Tianyan Zhou*. Simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat plasma using HPLC with on-line solid-phase extraction. J Chromatogr B , (2011) accepted

3. Li,Liang; Li, Zaiquan; Deng,Chenhui; Ning, Miaoran; Li, Hanqing; Bi, Shanshan; Zhou, Tianyan* and Lu, Wei*. Mechanism-based Pharmacokinetic/Pharmacodynamic Model for CYP3A1/2 Induction by Dexamethasone in Rats. Acta Pharmacologica Sinica, (2011), accepted

4. Li, HanQing; Li, MengYao; Li, ZaiQuan; Li, Liang; Bi, ShanShan; Deng, ChenHui; Chen, Rui; Zhou,TianYan* and Lu, Wei*. New synthetic route of two active isomeric metabolites of erlotinib and their bioactivity studies against several tumor cell lines. Chinese Journal of Chemistry, (2011), 29(8), 1709-1714.

5. Huang, Chaoqun; Zhou,Tianyan; Chen, Yue; Sun, Teng; Zhang, Shunfen; Chen, Guangping. Estrogen-related receptor ERR-mediated downregulation of human hydroxysteroid sulfotransferase (SULT2A1) in Hep G2 cells. Chemico-Biological Interactions, (2011), 92, 264–271.

6. Huang, Chaoqun; Zhou, Tianyan; Chen, Yue; Zhang, Shunfen; Chen, Guangping. (-) epicatechin regulation of hydroxysteroid sulfotransferase STa (rSULT2A1) expression in female rat steroidogenic tissues.Journal of Pharmacology and Toxicology, (2011), 6(4), 349-360.

7. Zhou, Tianyan; Huang, Chaoqun; Chen, Yue; Shanbhag, Preeti; Chen, Guangping. Methamphetamine regulation of sulfotransferases in rat liver and brain. American Journal of Pharmacology and Toxicology, (2010), 5(3), 125-132.

8. Zhou, Tianyan; Li, Xinming; Ng, Magdeline Tao Tao; Wang, Yifan; Quek, Ngee Mien; Luo, Ji; Yuan, Weixing; Tan, Choon-Hong; Zeng, Huaqiang; Li, Tianhu. Synthesis and Characterization of Circular Structures of i-Motif Tagged with Fluoresceins. Bioconjugate Chemistry, (2009), 20(4), 644-647.

9. Zhou, Tianyan; Wang, Yifan; Li, Xinming; Zhang, Qiang; Li, Tianhu. Synthesis and characterization of a fluorescein-labeled circular G-quadruplex. Bulletin of the Chemical Society of Japan, (2006), 79(8), 1300-1302.

10. Zhou, Tianyan; Chen, Guoshu; Wang, Yifan; Zhang, Qiang; Yang, Ming; Li, Tianhu.Synthesis of unimolecularly circular G-quadruplexes as prospective molecular probes. Nucleic Acids Research (2004), 32(21), e173/1-e173/9.