北京大学

刘  艳   副教授, 硕士生导师

北京大学药学院药剂学系副主任

北京市海淀区学院路38号，邮编  100191

Tel: (+8610) 82801508

Email: yanliu@bjmu.edu.cn

1986年在山东大学化学系获得理学学士学位。1989年在山东大学化学系获得理学硕士学位。同年8月到北京医科大学药学院工作。1998-2000年到德国雷根斯堡大学化学与药学系工作与学习。2000年至今，任北京大学药学院药剂学系副教授。讲授物理化学、物理药剂学和分散体系的物理化学等本科、硕士和博士研究生课程。担任《化学学报》、《药学学报》、《中国药学杂志》、《中国新药杂志》、International Journal of Pharmaceutics、Biomaterials等多个学术期刊的评审。主持或参加的基金项目包括国家自然科学基金、973重大研究计划、国家重大新药创制专项新剂型与新释药系统技术平台等。在国内、外学术期刊上发表论文60余篇。主编教材或专著5部，主译专著1部，参编教材2部。申请国家发明专利16项。主持完成了数个药物制剂的研究开发工作。

研究兴趣

物理药剂学。主要涉及以下研究领域

1. 新型纳米载体系统与靶向给药

2. 药用高分子材料的分子设计、合成与性能评价

3. 药物多晶型

代表性论文

1. Xiaoning Wang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) hydrogels. Acta Biomaterialia, 2011, 7: 4149-4159.

2. Xinru Li, Yuanting Yue, Yanxia Zhou, Yan Liu*, et al. An oil-free microemulsion for intravenous delivery of diallyl trisulfide: Formulation and evaluation. International Journal of Pharmaceutics, 2011, 407:158-166.

3. Xinru Li, Yanhui Zhang, Yating Fan, Yan Liu*, et al. Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol. Nanoscale Research Letters, 2011, 6:275.

4. Xingwei Chen, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: preparation, characterization and in vivo evaluation. Journal of Biomaterials Applications, online on July 12, 2011. doi:10.1177/0885328211406563.

5. Yating Fan, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Improved intestinal delivery of salmon calcitonin by water-in-oil microemulsions. International Journal of Pharmaceutics, 2011, 416:323-330.

6. Yanhui Zhang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Cyclosporine A-loaded poly(ethylene glycol)-b-poly(D,L-lactic acid)  micelles: preparation, in vitro and in vivo characterization and transport mechanism across the intestinal barrier. Molecular Pharmaceutics, 2010, 7(4):1169-1182.

7. Wang Fei, Li Xinru, Zhou Yanxia, Yan Liu*, et al. Novel nanoscaled polyion complex micelles for targeted delivery of recombinant hirudin to platelets based on cationic copolymer. Molecular Pharmaceutics, 2010, 7(3):718-726.

8. Xinru Li, Pingzhu Li, Yan Liu*, et al. Novel mixed polymeric micelles for enhancing delivery of anticancer drug and overcoming multidrug resistance in tumor cell lines simultaneously. Pharmaceutical Research, 2010, 27(8):1498-1511.

9. Xinru Li, Xiaoyan Li, Yanxia Zhou, Yan Liu*, et al. Development of patch and spray formulations for enhancing topical delivery of   sinomenine hydrochloride. Journal of Pharmaceutical Sciences, 2010, 99(4):1790-1799.

10. Yanhui Zhang, Xinru Li, Yanxia Zhou, Yan Liu*, et al. Preparation and evaluation of poly(ethylene glycol)–poly(Lactide) micelles as nanocarriers for oral Delivery of cyclosporine A. Nanoscale Resrarch Letters, 2010, 5:917-925.

11. Xinru Li, Quan Yuan, Yanqing Huang, Yanxia Zhou, and Yan Liu*. Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability. AAPS PharmSciTech, 2010, 11(2):672-678.

12. Ming Chen , Xin-Ru Li, Yan-Xia Zhou, Yan Liu*, et al. Improved absorption of salmon calcitonin by ultraflexible liposomes  through intranasal delivery. Peptides, 2009,30:1288-1295.

13 Kewei Yang, Xinru Li, Zhuoli Yang, Yan Liu*, et al. Novel polyion complex micelles for liver-targeted delivery of diammonium glycyrrhizinate: in vitro and in vivo characterization. Journal of Biomedical Materials Research Part A, 2009, 87(4):140-148.

14. Xinru Li, Yanqing Huang, Xingwei Chen, Yanxia Zhou, Yan Liu*, et al. Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin. Journal of Drug Targeting, 2009, 17(10):739-750.

15. Xinru Li, Zhuoli Yang, Kewei Yang, Yan Liu*, et al. Self-assembled polymeric micellar nanoparticles as nanocarriers for poorly soluble anticancer drug ethaselen. Nanoscale Resrarch Letters, 2009, 4:1502-1511.

16. Zhuoli Yang, Xinru Li, Kewei Yang, Yan Liu*. Amphotericin B-loaded poly(ethylene glycol)-poly(lactide) micelles: preparation, freeze-drying and in vitro release. Journal of Biomedical Materials Research Part A, 2008, 85(2):539-546.