中国水产科学研究院长江水产研究所导师信息介绍：李志华

个人简历

姓名：李志华

性别：男

民族：汉

出生日期：1979年6月

籍贯：河北省辛集市

工作单位：中国水产科学研究院长江水产研究所研究员

通信地址：湖北省武汉市东湖新技术开发区武大园一路8号，430223

电子邮件: lzhyfi@126.com; zhihuali06@yahoo.com

现为长江水产研究所水生态毒理学科负责人。博士毕业于捷克南波希米亚大学，长期从事水生态毒理学研究。2010年赴美国加州大学河滨分校Prof. DanelSchlenk实验室访问交流，主要是对水体中污染物对小型鱼类的神经行为学影响进行研究。2011年-2012年期间，在新加坡国立大学从事博后研究，主要研究方向是利用斑马鱼做为模式生物进行毒理基因组学影响。

到2014年为止，以第一作者发表34 篇（总共发表47篇），最高影响因子8.633，文章总被引超过521次（他引382次），最高单篇被引用为44次，H-index=14。目前担任SCI刊物Bulletin of Environmental Contamination and Toxicology（IF=1.316）的编委和BioMed Research International（IF=2.880）专刊的客座编辑，并担任PLoS ONE, AquaticToxicology等22种该领域SCI期刊的独立审稿人。现为科技部国际合作专项评审专家库成员，中国环境科学学会理事会员，中国毒理学会环境与生态毒理专业委员会会员和中国化学学会会员。

国外留学期间获得奖励包括：南波西米亚大学渔业与水保护学院35岁以下青年优秀科研成果一等奖（2009）；国家优秀自费留学生奖学金（2010）；南波西米亚大学优秀科技成果校长奖（2011）。

研究兴趣：

目前主要是利用各种生物标志物对水环境中的污染物进行生态健康评价，工作主要从两方便展开，一是将水环境中典型污染物的生态毒性效应及分子机制研究，主要以淡水鱼类作为活体模型，将微观与宏观相结合，从分子/生化/生理/个体层次上进行，并建立之间的联系，探索污染物对水生生物的生殖毒性、神经毒性、发育毒性、健康危害，以及多种污染物在环境条件下的复合作用，通过转录组、蛋白质组学分析来表征污染物的制毒作用机制，从而为污染物的危险评价以及为我国可持续发展战略、生态安全及环境保护决策提供理论依据；二是针对新兴污染物（如药物残留活性物质、人工纳米污染物等）的分子标记物的筛选及其环境健康风险评估，主要以小型淡水鱼类（如斑马鱼、青鳉等）为动物模型，从转录组学和蛋白质组学角度研究动物有关基因在不同环境胁迫下的表达与调控、以及蛋白质谱的变化，在分子水平寻找人类及动物典型污染物暴露的更敏感、有效的生物标记物，发展环境污染的早期预警系统，并通过比较生物学，找出该污染物在其他哺乳动物和人类的保守基因或信号通路，以便对污染物的环境健康风险评估提供科学依据。

近期主持课题情况：

2010，残留药物维拉帕米长期暴露对虹鳟蛋白组学及抗氧化反应的影响 (南波西米亚大学课题，007/2010/Z)

2012-2014， -利用被动采样/质谱技术对长江爱那个流域新型污染物的检测及鉴定 (中捷政府间科技合作项目，LH12179)

2013-2015，气体过饱和、重金属和典型有机污染物对鱼类等水生生物影响机理研究（三峡总公司课题-重金属部分，07011034）

2013-2014，三峡库区水体中典型环境激素有机锡化合物的生态毒理学研究（农业部留学人员科技活动择优资助项目）

2014-2016，环境激素三丁基锡对鲤鱼的危害及其机制（中国水产科学研究院基本科研业务费，2014A02YQ01）

2015-2016，不同温度下草鱼幼鱼对汞胁迫的耐受性研究（湖北省自然基金，2014CFB266）

2015-2017，温度对草鱼幼鱼在低剂量汞胁迫下毒代动力学及生理应答影响研究（国家自然科学基金，21407181）

近五年获奖情况：

2009，南波西米亚大学渔业与水保护学院35岁以下青年优秀科研成果一等奖；

2010，国家优秀自费留学生奖学金；

2011，南波西米亚大学优秀科技成果校长奖。

学术兼职

SCI刊物编辑：Bulletin of Environmental Contamination and Toxicology

SCI刊物特约编辑：BioMed Research International专刊“Fish and Crayfish Toxicology”和“Endocrine Toxicology in Aquatic System”

SCI刊物独立审稿人：PLoS ONE, Water Research, Journal of Hazardous Materials, Chemosphere, BMC Veterinary Research, Science of the Total Environment, Comparative Biochemistry and Physiology-Part B, Part C, Environmental Toxicology and Chemistry, Mutation Research, Ecotoxicology and Environmental Safety, Environmental Toxicology, Experimental and Molecular Pathology, Marine Environmental Research, Aquaculture Nutrition, Food and Chemical Toxicology, Diseases of Aquatic Organisms, Journal of Environmental Management, Fish Physiology and Biochemistry, Bulletin of Environmental Contamination and Toxicology, Aquaculture research, Reproductive Biology, Acta veterinaria Brno.

中国环境科学学会理事会员，中国毒理学会环境与生态毒理专业委员会会员和中国化学学会会员。

河北大学、华中农业大学、上海海洋大学硕士研究生导师。

近五年以第一作者发表SCI文章列表

2014之后：

Li Z.H*., Chen L., Wu Y.H., Li P., Li Y.F.,& Ni Z.H. 2014. Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 161, 53-57.

Li Z.H*., Chen L., Wu Y.H., Li P., Li Y.F.,& Ni Z.H. 2014. Effects of mercury on oxidative stress and gene expression of potential biomarkers in larvae of the Chinese rare minnow Gobiocypris Rarus. Archives of Environmental Contamination and Toxicology, 67, 245-251.

Li Z.H*., Chen L., Wu Y.H., Li P., Li Y.F.,& Ni Z.H. 2014. Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride. Environmental Toxicology and Pharmacology, 38, 325-331.

Li Z.H*., Li P.,& Shi Z.C. 2014. Molecular responses in digestive tract of juvenile common carp after chronic exposure to sublethal tributyltin. Ecotoxicology and Environmental Safety, 109, 10-14.

Li, Z.H*., Li, P., Chen, L., 2014. Temperature affects Hg-induced antioxidant responses in Chinese rare minnow Gobiocypris rarus larvae in vitro. Bulletin of Environmental Contamination and Toxicology,93, 666-669.

Li, Z.H*., Li, P. 2015. Evaluation of tributyltin toxicity in Chinese rare minnow larvae by abnormal behavior, energy metabolism and endoplasmic reticulum stress. Chemico-Biological Interactions, 227, 32–36

Li Z.H*., Li P.,& Shi Z.C. 2015.Responses of the hepatic glutathione antioxidant defense system and related gene expression in juvenile common carp after chronic treatment with tributyltin. Ecotoxicology, 24, 700-705.

Li Z.H*., Li P.,& Shi Z.C. 2014.Chronic effects of tributyltin on multiple biomarkers responses in juvenile common carp, Cyprinus carpio. Environmental Toxicology. accepted.

Li Z.H*., Li P.,& Shi Z.C. 2014.Alterationof antioxidant response and expression of related genes by Cadmium in Chinese rare minnow larvae. CLEAN - Soil, Air, Water. accepted.

Li Z.H*., Li P.,& Shi Z.C. 2014.Physiological and molecular responses in brain of juvenile common carp (Cyprinus carpio) following exposure to tributyltin. Environmental Toxicology. accepted.

Li Z.H*., Li P.,& Shi Z.C. 2015.Chronic exposure to tributyltin induces brain functional damage in juvenile common carp (Cyprinus carpio) PLoS ONE. accepted.

2014年之前:

Li, Z.H., Xu, H.Y., Zheng, W.L., Lam, S.H., Gong, Z.Y*. 2013. RNA-sequencing analysis of TCDD-induced responses in zebrafish liver reveals high relatedness to in vivo mammalian models and conserved biological pathways. PLoS ONE, 8(10): e77292.

Li, Z.H.*, Zlabek, V., Velisek, J., Grabic, R., Machova, J., Kolarova, J., Li, P., Randak, T. 2013. Multiple biomarkers responses in juvenile rainbow trout, Oncorhynchus mykiss, after acute exposure to a fungicide propiconazole. Environmental Toxicology 28(3):119-126.

Li, Z.H*., Li, P., Sulc, M., Hulak, M., Randak, T., 2012. Hepatic proteome sensitivity in rainbow trout after chronically exposed to a human pharmaceutical Verapamil. Molecular and Cellular Proteomics, 11(1): M111.008409.

Li, Z.H*., Zlabek, V., Turek, J., Velisek, J., Pulkrabova, J., Kolarova, J., Sudova, E., Berankova, P., Hradkova, P., Hajslova, J., Randak, T., 2011. Evaluating environmental impact of STPs situated on streams in the Czech Republic: An integrated approach to biomonitoring the aquatic environment. Water Research 45 (3): 1403-1413.

Li, Z.H*., Velisek, J., Zlabek, V., Grabic, R., Machova, J., Kolarova, J., Li, P., Randak, T., 2011. Chronic toxicity of Verapamil on juvenile rainbow trout (Oncorhynchus mykiss): effects on morphological indices; hematological parameters and antioxidant responses. Journal of Hazardous Materials 185 (2-3): 870-880.

Li Z.H*., Velisek J., Grabic R., Li P., Kolarova J., Randak T. 2011. Use of hematological and plasma biochemical parameters to assess the chronic effects of a fungicide Propiconazole on a freshwater teleost. Chemosphere, 83(4): 572-578.

Li, Z.H*., Li, P., Randak, T. 2011. Evaluating the toxicity of environmental concentrations of waterborne chromium (VI) to a model teleost, Oncorhynchus mykiss: a comparative study of in vivo and in vitro. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 153(4): 402-407.

Li, Z.H*., Zlabek, V., Li, P., Grabic, R., Velisek, J., Machova, J., Randak, T., 2011. Acute toxicity of carbamazepine to juvenile rainbow trout (Oncorhynchus mykiss): effects on antioxidant responses, hematological parameters and hepatic EROD. Ecotoxicology and Environmental Safety 74 (3): 319-327.

Li Z.H*., Li P., Randak T. 2011.Protective roles of calcium channel blocker against cadmium-induced physiological stress in freshwater teleost Oncorhynchus mykiss. Water, Air, & Soil Pollution 220 (1-4):293-299.

Li, Z.H*., Zlabek, V., Grabic, R., Li, P., Randak, T., 2011. Biochemical responses in gill of rainbow trout exposed to propiconazole. Central European Journal of Biology 6 (1): 84-90.

Li, Z.H*., Zlabek, V., Velisek, J., Grabic, R., Machova, J., Kolarova, J., Li, P., Randak, T., 2011. Antioxidant responses and plasma biochemical characteristics in the freshwater rainbow trout, Oncorhynchus mykiss, after acute exposure to the fungicide propiconazole. Czech Journal of Animal Science 56(2):64-72.

Li, Z.H*., Zlabek, V., Grabic, R., Li, P., Machova, J., Velisek, J., Randak, T., 2010. Effects of exposure to sublethal propiconazole on the antioxidant defense system and Na+-K+-ATPase activity in brain of rainbow trout, Oncorhynchus mykiss. Aquatic Toxicology 98(3): 297-303.

Li, Z.H*., Li, P, Rodina, M, Randak, T., 2010. Evaluating the function of calcium antagonist on the cadmium-induced stress in sperm of Russian sturgeon, Acipenser gueldenstaedtii. Aquatic Toxicology 100(4): 373-375.

Li, Z.H*., Li, P, Rodina, M, Randak, T., 2010. Effect of human pharmaceutical Carbamazepine on the quality parameters and oxidative stress in common carp (Cyprinus carpio L.) spermatozoa. Chemosphere 80(5): 530-534.

Li, Z.H*., Velisek, J., Zlabek, V., Grabic, R., Machova, J., Randak, T., 2010. Enzymatic alterations and RNA/DNA ratio in intestine of rainbow trout, Oncorhynchus mykiss, induced by chronic exposure to carbamazepine. Ecotoxicology 19(5): 872–878.

Li, Z.H*., Velisek, J., Zlabek, V., Grabic, R., Machova, J., Kolarova, J., Randak, T., 2010. Hepatic antioxidant status and haematological parameters in rainbow trout, Oncorhynchus mykiss, after chronic exposure to carbamazepine. Chemico-Biological Interactions 183(1): 98-104.

Li, Z.H*., Zlabek, V., Grabic, R., Li, P., Machova, J., Velisek, J., Randak, T., 2010. Effects of exposure to sublethal propiconazole on intestine-related biochemical responses in rainbow trout, Oncorhynchus mykiss. Chemico-Biological Interactions 185(3): 241-246.

Li, Z.H*., Li, P., Dzyuba, B., Randak, T., 2010. Influence of environmental related concentrations of heavy metals on motility parameters and antioxidant responses in sturgeon sperm. Chemico-Biological Interactions 188(3): 473-477.

Li, Z.H*., Zlabek, V., Velisek, J., Grabic, R., Machova, J., Randak, T., 2010. Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 151(1): 137-141.

Li, Z.H*., Li, P., Randak, T., 2010. Ecotoxocological effects of short-term exposure to a human pharmaceutical Verapamil in juvenile rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 152(3): 385-391.

Li, Z.H*., Zlabek, V., Grabic, R., Li, P., Randak, T., 2010. Modulation of glutathione-related antioxidant defense system of fish, chronically treated by the fungicide propiconazole. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 152(3): 392-398.

Li, Z.H*., Zlabek, V., Li, P., Grabic, R., Velisek, J., Machova, J., Randak, T., 2010. Biochemical and physiological responses in liver and muscle of rainbow trout after long-term exposure to propiconazole. Ecotoxicology and Environmental Safety 73(6): 1391-1396.

Li, Z.H*., Zlabek, V., Velisek, J., Grabic, R., Machova, J., Randak, T., 2010. Physiological condition status and muscle-based biochemical responses in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine. Journal of Applied Toxicology 30(3): 197-203.

Li, Z.H*., Zlabek, V., Velisek, J., Grabic, R., Machova, J., Randak, T., 2009. Responses of antioxidant status and Na+-K+-ATPase activity in gill of rainbow trout, Oncorhynchus mykiss, chronically treated with carbamazepine. Chemosphere 77(11):1476-1481.

Li, Z.H*., Li, P., Randak, T., 2009. Effect of a human pharmaceutical carbamazepine on antioxidant responses in brain of a model teleost in vitro: An efficient approach to biomonitoring. Journal of Applied Toxicology 30(7): 644-648.

Li, Z.H*., Xie, S., Wang, J.X., Sales, J., Li, P., Chen, D.Q., 2009. Effect of intermittent starvation on growth and some antioxidant indexes of Macrobrachium nipponense (De Haan). Aquaculture research 40(5): 526-532.

Li, Z.H*., Randak, T., 2009. Residual pharmaceutically active compounds (PhACs) in aquatic environment: status, toxicity and kinetics. Veterinarni Medicina 52 (7): 295-314.

Li, P.*, Li, Z.H.*, Hulak, M., Rodina, M., Linhart, O., 2012. Regulation of spermatozoa motility in response to cations in Russian sturgeon (Acipenser gueldenstaedtii). Theriogenology 78(1):102-109 (IF = 2.521) (* corresponding author)