北京大学药学院化学生物学专业硕士研究生导师信息：葛泽梅

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葛泽梅：副教授，硕士生导师。

Tel: 010-82801504

E-mail: zmge@bjmu.edu.cn

通讯地址：北京市海淀区学院路38号药学楼504室 邮编：100191

多年来一直从事有机化学、药物化学、化学生物学的科研与教学工作。主要研究方向为基于作用机制的杂环类化合物的设计、合成、合成方法及生物活性研究。已主持完成国家自然科学基金2项，作为主要参加者完成国家自然科学基金3项以及“973”子课题等。目前主持或承担国家“十一五”“北京大学综合性创新药物研究开发技术大平台”的候选药物研究品种及新药临床前研究课题。在国内外学术刊物上发表论文40余篇，申请专利6项。

主要研究领域：

1. 基于作用机制的杂环类化合物的设计、合成、合成方法及生物活性研究

2. 氨基二硫代甲酸酯类化合物的设计、合成及抗肿瘤活性研究

3. 新型酪氨酸激酶抑制剂的设计、合成及活性研究

4. 硫醇替代试剂的应用扩展与研究

代表性论文

1.Ri-Dong Li, Xin Zhang, Qiao-Yan Li, Ze-Mei Ge*, Run-Tao Li* ,Novel EGFR inhibitors prepared by combination of dithiocarbamic acid esters and 4-anilinoquinazolines. Bioorg. Med. Chem. Lett. 2011, 21, 3637–3640.

2.Wang, Junfeng; Qi, Chao; Ge, Zemei*; Cheng, Tieming; Li, Runtao*. Efficient direct asymmetric vinylogous Michael addition reactions of g -butenolides to chalcones catalyzed by vicinal primary-diamine salts Chem. Commun., 2010, 46, 2124–2126 .

3.Wang, Junfeng; Li, Qin; Qi, Chao; Liu, Yi; Ge, Zemei*; Li, Runtao*. Primary 1,2-diamine catalysis III: an unexpected domino reaction for the synthesis of multisubstituted cyclohexa-1,3-dienamines. Organic & Biomolecular Chemistry,  (2010),  8(19),  4240-4242.

4.Wang, Junfeng; Wang, Xin; Ge, Zemei*; Cheng, Tieming; Li, Runtao*. Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism. Chem. Commun., 2010, 46, 1751–1753 .

5.MENG LEI, SHUAI XIA, JUNFENG WANG, ZEMEI GE,* TIEMING CHENG, AND RUNTAO LI*，An Efficient Dipeptide-Catalyzed Direct Asymmetric Aldol Reaction of Equimolar Reactants in Solid Media，CHIRALITY, 22:580–586 (2010).

6.Fang-bin Han,Ze-mei Ge,*Tie-ming Cheng,Run-tao Li* ,Novel One-Pot, Four-Component Synthesis of 3-Alkyldithiocarbonyl-oxazolidines from Aminoethanols, Ketones, Carbon Disulfide, and Halides, Synlett., 2009, 4, 648-650.

7.Zhong-qing Wang, Ze-mei Ge,* Tie-ming Cheng, Run-tao Li*, Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water, Synlett., 2009, 7, 2020-2022.

8.Jun-feng Wang, Meng Lei, Qin Li, Ze-mei Ge,* Xin Wang, Run-tao Li*, A novel and efficient direct aldol condensation from ketones and aromatic aldehydes catalyzed by proline–TEA through a new pathway, Tetrahedron.65(2009), 4826-4833

9.ZHU, Jirang(朱继让), LI, Ridong(李日东), GE, Zemei*(葛泽梅), CHENG, Tieming(程铁明), LI, Runtao*(李润涛),  Synthesis of β-Hydroxy Sulfides via Thiolysis of Epoxides Using S-Alkylisothiouronium Salts as Thiol Equivalents in Basic Aqueous Medium, Chinese Journal of Chemistry, 2009, 27, 791-796.

10.WANG, Zhongqing(王仲清), GE, Zemei*(葛泽梅), CHENG, Tieming(程铁明), LI, Runtao*(李润涛), An Efficient Four-Component, One-Pot Synthesis of  Poly-Substituted Pyrimidines in Water, Chinese Journal of Chemistry, 2009, 27, 834-838.

11.XuYan, Ze­Mei Ge*,Tie­Ming Cheng and Run­Tao Li*, One­pot synthesis of 1,3,4­oxadiazole­5­thioethers in water, Journal of Chinese Pharmaceutical Sciences 17 (2008 ) 277-280.

12.Song-wen Lin,a Qi Sun,a Run-tao Li,*a,b Tie-ming Cheng,a Ze-mei Ge*a, Potassium Phosphate Promoted Aza-Markovnikov Addition of N-Heterocycles to Vinyl Esters. Synthesis, 2007, 13, 1933-1938.

13.Yan Zhao,a Ze-Mei Ge,*a Tie-Ming Cheng,a Run-Tao Li*a,b, Thia-Michael Addition Using Cheap and Odorless S-Alkylisothiouronium Salts as Thiol Equivalents in Water. Synlett.,  2007, 10, 1529-1532.

14.Qi Sun, Run-Tao Li, Wei Guo, Jing-Rong Cui, Tie-Ming Cheng and Ze-Mei Ge,* Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP), Bioorganic & Medicinal Chemistry Letters, 2006, 16, 3727-3730.

15.GE, Ze-Mei, LI, Qin, ZHENG, Shao-Jun, CHENG, Tie-Ming, CUI, Yu-Xin, LI, Run-Tao*, Facile One-pot Synthesis of Ethyl 3-Alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylates, Chinese Journal of Chemistry, 2006, 24, 381-385.

16.Ze-mei Ge, Jia-ling Cui, Yan-ling Wang, Tie-ming Cheng, Run-tao Li*. A mild and efficient synthesis of 4, 5-disubstituted 3-amino-4-hydroxythiazolidine-2-thiones and S, N- disubstituted 1, 3, 4- thiadiazole-2-thiones. Synthesis, 2004, 8, 1257-1261.