兰州大学

王凯荣，男，博士，副教授，硕士生导师。 2009 年于兰州大学获得理学博士学位，同年留校在医学生物化学与分子生物学研究所从事教学科研工作，主要从事多肽药物分子设计、合成及抗菌肽抗肿瘤、抗菌、抗真菌、抗病毒活性、作用机制及构效关系研究。2012年获第十二届中国国际多肽学术会议青年论文奖（Young Peptide Scienctist Award）;2013年10月获第十二届张锡均基金会全国青年优秀生理学学术论文优秀口头报告奖（中国生理学会）。
邮箱: wangkr@lzu.edu.cn 

大学开始受教育经历

2000.9-2004.7 西北师范大学生命科学学院，获得学士学位。
2004.9-2009.7 兰州大学生命科学学院，生物化学与分子生物学专业，获得博士学位。

研究工作经历

2009.7—2012.5  兰州大学，基础医学院/甘肃省新药临床前研究重点实验室,讲师；
2012.5—   兰州大学，基础医学院/甘肃省新药临床前研究重点实验室，副教授，硕士生导师。

在研项目：

1.教育部“春晖计划”合作科研项目“抗菌肽优化设计合成、构效关系及膜-肽作用分子动力学机制研究”（No.Z2010082）， 2011.7—2013.7；
2.教育部博士点新教师基金项目“抗菌肽polybia-MPI 的新型类似物的设计合成、抗菌活性及构效关系研究”（No.20120211120045）， 2013.1-2015.12；
3.国家自然科学基金青年基金项目“以细胞膜为靶标的新型抗菌肽polybia-MPI类似物的设计、合成及抗菌活性研究”（No.31200584）, 2013.01-2015.12；
4.兰州大学中央高校自由探索面上项目“新型抗菌肽氟代衍生物抗真菌活性、作用机制及构效关系研究”(No.lzujbky-2013-164)，2013.1-2014.6。

已发表论文目录:

1. Kairong Wang, JX Yan, W Dang, JQ Xie, Bo Yan, Wenjin Yan, et al. Dual Antifungal properties of Cationic Antimicrobial Peptides Polybia-MPI: Membrane Integrity Disruption and Inhibition of Biofilm Formation. Peptides 2014, 10.1016/j.peptides.2014.03.005. (SCI)
2. Kairong Wang, W Dang, JX Yan, R Chen, X Liu, WJ Yan, et al. Membrane Perturbation Action Mode and Structure-Activity Relationships of Protonectin, a Novel Antimicrobial Peptide from the Venom of the Neotropical Social Wasp Agelaia pallipes pallipes. Antimicrobial Agents and Chemotherapy, 2013,57(10), 4632–9. (SCI二区， IF=4.841)
3. Kairong Wang, J Yan, W Dang, X Liu, R Chen, J Zhang, B Zhang, W Zhang, M Kai, W Yan, Z Yang, J Xie, Rui Wang. Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista. Peptides 2013, 39,80–88. （SCI三区，IF=2.421）
4. J Yan1, Kairong Wang1, W Dang, R Chen, J Xie, B Zhang, J Song, Rui Wang. Two Hits Are Better than One: Membrane-Active and DNA Binding-Related Double-Action Mechanism of NK-18, a Novel Antimicrobial Peptide Derived from Mammalian NK-Lysin. Antimicrob. Agents Chemother., 2013; 57: 220 - 228. (并列第一作者，SCI二区，IF=4.841)
5. D Wang, J Liang, J Feng, Kairong Wang, Q Sun, L Zhao, D Li, W Yan and Rui Wang. The Quinine Thiourea-Catalyzed Asymmetric Strecker Reaction: An Approach for the Synthesis of 3-Aminooxindoles. Adv. Synth. Catal. 2013, 355:548-58. （SCI二区, IF=6.048）
6. Kairong Wang, J Yan, R Chen, W Dang, B Zhang, W Zhang, J Song, Rui Wang. Membrane-Active Action Mode of Polybia-CP, a Novel Antimicrobial Peptide Isolated from the Venom of Polybia paulista. Antimicrob. Agents Chemother., 2012; 56: 3318 - 3323. （SCI二区， IF=4.841）
7. J Yan1, Kai-rong Wang1, J Song, R Chen, B Zhang, W Zhang, W Dang, Rui Wang. Membrane active antitumor activity of NK-18, a mammalian NK-lysin-derived cationic antimicrobial peptide. Biochimie  2012,94 184-191. (SCI三区, 并列第一作者，IF =3.787).
8. Kairong Wang, J Yan, X Liu, J Zhang, R Chen, B Zhang, W Dang, et al. Novel cytotoxity exhibition mode of polybia-CP, a novel antimicrobial peptide from the venom of the social sasp polybia paulista. Toxicology, 2011, 288; 27-33. (SCI二区, IF =4.01)
9. B Zhang1, Kai-rong Wang1, W Zhang, J Yan, J Song, Rui Wang . In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides. Peptides. 2010,31, 568–573. (SCI三区，并列第一作者, IF =2.434)
10. Rui Wang, Kairong Wang. Peptides: Chemistry, Biology and Pharmaceutical Sciences, Chemical Industry Press, 2011.
11. B Zhang, Kairong Wang, Z Wang, X Li, X Wang, J Ni. Design, synthesis and in vitro antitumor activity of novel actinomycin D analogs. Chemical Journal of Chinese Universites. 2010,31,1346-1352.（SCI三区, IF =0.855）
12. Kai-rong Wang, J Yan, B Zhang, J Song, P Jia, Rui Wang. Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells. Cancer lett. 2009, 278,65-72.(SCI二区, IF =4.238)
13. Kai-rong Wang, B Zhang, J Yan, X Li, Rui Wang. Potent antitumor effects of a novel actinomycin D analog Leu5AMD, Cancer lett. 2008,268,38-45. (SCI二区, IF =4.238)
14. Kai-rong Wang, Bang-zhi Zhang, Jie-xi Yan, Jia Li, Rui Wang. Antitumor effects, cell selectivity and structure–activity relationship of a novel antimicrobial peptide polybia-MPI. Peptides. 2008,29,963-8. (SCI三区, IF 2.434).
15. C Fu, Z Kong1, Kai-rong Wang1, Q Yang, K Zhai, Q Chen, Rui Wang. Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on nociception in mice. Brain Res.,2005,1056,51-58.(SCI三区, IF 2.434,)
16. C Fu1, Q yang1, Kai-rong Wang, Z Kong, Q Chen, Rui Wang. Rat/mouse hemokinin-1, a mammalian tachykinin peptide, markedly potentiates the antinociceptive effects of morphine administered at the peripheral and supraspinal level. Behavioural Brain Research, 2006, 170: 293-301. (SCI三区, IF 3.393)
17. W Zhang, J Li, L Liu, Kai-rong Wang, J Song, J Yan, Z Li, B Zhang, RuiWang. A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic ef?cacy against cancer and diminished toxicity in mice. Peptides. 2010,31,1832–1838.（SCI三区, IF =2.434）
18. W Zhang, J Song, B Zhang, L Liu, Kairong Wang, Rui Wang. Design of acid-activated cell penetrating peptide for delivery of active molecules into cancer cells. Bioconjugate Chem., 2011, 22 (7), 1410–1415 (SCI二区，IF=4.93)
19. W Zhang, J Song, L Mu, B Zhang, L Liu, Y, Xing, Kai-rong Wang, Z Li, Rui Wang. Improving anticancer activity and selectivity of camptothecin through conjugation with releasable substance P. Bioorganic & Medicinal Chemistry Letters.  2011, 21(5):1452-5 (SCI三区, IF=2.661)
20. Y Sun, X Zhang, N He, T Sun, Y Zhuang, Q Fang, Kai-rong Wang, Rui Wang. Neuropeptide FF activates ERK and NF kappa B signal pathways in differentiated SH-SY5Y cells. Peptides, 2012, 38, 110–117.（SCI三区，IF=2.434）.