华中农业大学

匡汉晖，男，1967年生于江西泰和。1988年获江西农业大学学士学位；1991年获北京林业大学硕士学位；1994-1998年在美国佐治亚大学(University of Georgia)学习，获博士学位。博士毕业后于1998-2007年分别在以色列海法大学(University of Haifa)、美国加州大学戴维斯分校(University of California, Davis)和伯克莱分校(University of California, Berkeley)从事蔬菜抗病研究工作, 研究内容包括植物抗病基因的基因组学、群体遗传学、分子进化、抗病基因克隆等。匡博士第一次详细论述植物中的抗病基因不同的进化速度，为抗病基因的保存、利用以及快速克隆提供理论基础。2008年受聘为长江学者特聘教授。现为华中农业大学园艺林学学院蔬菜系教授，博士生导师。

联系电话：027-87280752

Email: kuangfile@mail.hzau.edu.cn

研究方向：

课题组的研究领域是植物分子遗传和基因组学。具体研究方向是植物抗病基因以及蔬菜特异性状的遗传和分子机理。现有（2014）研究课题为：

1、抗病基因基因组学：植物中的抗病基因的全基因组分析，侧重其分子进化

2、抗病基因的快速克隆。利用第二代测序技术与BSA相结合快速定位抗病基因。利用VIGS技术快速鉴定抗性候选基因

3、蔬菜花青素高含量的遗传与分子机理。通过遗传方法定位和克隆调控花青素含量的基因，并分析其作用机理。

4、变态膨大茎的遗传和分子机理。莴笋、榨菜、苤蓝等变态茎膨大的遗传和分子机理。

5、生菜、甘蓝结球性状的遗传和分子机理。

6、生菜不同叶型发育的分子机理

7、植物中微型转座子的基因组学

学术论文：

1.Wei, C., Kuang, H., Li, F., Chen, J. (2014) The I2 resistance gene homologues in Solanum have complex evolutionary patterns and are targeted by miRNAs. BMC Genomics, 15(1):743

2.Zhang, Y., Yan, C., Kuang, H*. (2014) GC-content fluctuation around small RNA-generating sites. FEBS Letters 588:764-769

3.Chen, J., Hu, Q., Zhang, Y., Lu, C., Kuang, H. (2014) P-MITE: a database for plant miniature inverted-repeat transposable elements. Nucleic Acids Res 42(1):D1176-81

4.Lin, X., Zhang, Y., Kuang, H., Chen, J. (2013) Frequent loss of lineages and deficient duplications accounted for low copy number of disease resistance genes in Cucurbitaceae. BMC Genomics 14:335

5.Jia, J.,…Kuang H (27th author).,…Wang, J., (2013) Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation. Nature, 496:91-5

6.Guo, S.…Kuang, H (31st author),…Xu, Y. et al., (2012) The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nat Genet. 45(1):51-8.

7.Xu, Q.,…Kuang, H. (34th author),…Ruan, Y. (2012) The draft genome of sweet orange (Citrus sinensis). Nat Genet. 16;45(1):59-66.

8.Yin, L.F., Hu, M.J,, Wang, F., Kuang, H., Zhang, Y., Schnabel, G., Li, G.Q., Luo, C.X. (2012) Frequent gain and loss of introns in fungal cytochrome B genes. PLoS One. 7 (11)

9.Chen, J., Lu, C., Zhang, Y., Kuang H. (2012) Miniature inverted-repeat transposable elements (MITEs) in rice were originated and amplified predominantly after the divergence of Oryza and Brachypodium and contributed considerable diversity to the species. Mob Genet Elements. 2(3):127-132.

10.Luo, S., Zhang, Y., Hu, Q., Chen, J., Li, Q., Lu, C., Liu, H., Wang, W., Kuang, H. (2012) Dynamic nucleotide-binding-site and leucine-rich-repeat-encoding genes in the grass family. Plant Physiol, 159:197-210

11.Lu, C., Chen, J., Zhang, Y., Hu, Q., Su, W., Kuang，H. (2012) Miniature inverted-repeat transposable elements (MITEs) have been accumulated through amplification bursts and play important roles in gene expression and species diversity in Oryza sativa. Mol Bio Evol, 29:1005-1017

12.Li G., Huang S., Guo X., Li Y., Yang Y., Guo Z., Kuang H., Rietman H., Bergervoet M., Vleeshouwers V., van der Vossen EA., Qu D., Visser R., Jacobsen E., Vossen J. (2011) Cloning and characterization of R3b; Members of the R3 superfamily of late blight resistance genes show sequence and functional divergence. Mol Plant Microbe Interact, 24:1132-1142

13.Xu, X.,…Kuang, H. (31st author),…Visser, RG.（2011）Genome sequence and analysis of the tuber crop potato. Nature 475:189–195

14.Luo, S., Peng, J., Li, K., Wang, M., Kuang, H.（2011）Contrasting evolutionary patterns of the Rp1 resistance gene family in different species of Poaceae. Mol Bio Evol,　 28: 313-325　　　　　　　　　　　　　　　　　　　　　　

15.Kuang, H.,Padmanabhan, C., Li, F., Kamei,A., Bhaskar, P. B., Ouyang, S., Jiang, J., Buell, C. R., C. R., and Baker, B.(2009) Identification of miniature inverted-repeattransposable elements (MITEs) and biogenesisof their siRNAs in the Solanaceae: New functionalimplications forMITEs. Genome Res, 19: 42-56.

16.Kuang, H., J. van Eck，H., Sicard，D., Michelmore, R. and Nevo, E. (2008) Evolution and genetic population structure of prickly lettuce (Lactuca serriola) and its RGC2 resistance gene cluster. Genetics, 178: 1547-1558.

17.Kuang, H., Caldwell, K., Meyers, B. and Michelmore, R. (2008) Frequent sequence exchanges between Homologs of RPP8 inArabidopsis are not necessarily associated with genomic proximity. Plant J, 54: 69-80.

18.Zhang, L., Mojtahedi, H., Kuang, H., Baker, B. and Brown, C.R. (2007) The use of STS markers in the marker-assisted selection of Columbia root-knot nematode resistance introgressed from Solanum bulbocastanum. Crop Sci, 47: 2021-2026

19.Kuang, H., Ochoa, O., Nevo E., and Michelmore R. (2006) The resistance gene Dm3 is infrequent in natural populations of Lactuca serriola due to deletions and frequent gene conversions. Plant J, 47: 38-48

20.Kuang, H., F. Wei, M. Marano, U. Wirtz, X. Wang, J. Liu, W. Shum,J. Zaborsky, L. J. Tallon, W. Rensink, S. Lobst, P. Zhang, C. Tornqvist, A. Tek, J. Bamberg, J. Helgeson, W. Fry, F. You, M. Luo, J. Jiang, R. C. Buell and B. Baker. (2005)The R1 resistance cluster contains three groups of independently evolving, Type I R1 homologues and shows substantial structural variation among haplotypes of Solanum demissum. Plant J, 44: 37-51

21.Huang, S., van der Vossen, E.A.G, Kuang, H., Vleeshouwers, V.G.A.A., Zhang, N., Borm, T.J.A., van Eck, H.J., Baker,B., Jacobsen, E. and Visser,R.G.F. (2005)Comparative genomics enabled the isolation of the R3a late blight resistance gene in potato. Plant J, 42: 251-261

22.Kuang, H., Woo, S., Meyers, B., Nevo, E., Michelmore, R. (2004) Multiple genetic processes result in heterogeneous rates of evolution within the major cluster disease resistance genes in lettuce. Plant Cell, 16: 2870-2894.

23.Meyers, B., Kozik, A., Griego, A., Kuang, H., R.W. Michelmore (2003). Genome-wide analysis of NBS-LRR-encoding genes in Arabidopsis. Plant Cell 15: 809-834.

24.Song, J., Bradeen, J.M., Naess, S.K., Raasch, J.A.,Haberlach, G.T., Wielgus S.M.,Liu, J., Kuang, H., Austin-Phillips, S., Buell, C.B., Helgeson, J.P., and Jiang, J. (2003) Gene RB from Solanum bulbocastanum confers broad spectrum resistance against potato late blight pathogen Phytophthora infestans. Proc Natl Acad Sci USA 100: 9128-9133.