北京化工大学

郭新东，教授

Email:xdguo@buct.edu.cn

http://www.microneedlelab.com/

教育/工作经历

2000-2004南京理工大学化工学院，学士

2004-2010华南理工大学化学与化工学院，博士

2007-2008新加坡生物工程与纳米技术研究院，联合培养博士生

2010-2013华南理工大学化学与化工学院，讲师

2011-2013美国佐治亚理工学院（GeorgiaTech）化工程系、生物医学工程系，博士后

2014-今北京化工大学材料学院，教授

研究领域

生物大分子高效递送系统研究

高分子微针的设计与开发

生物材料结构与性能关系研究

研究成果及获奖情况：

研究成果在Biomaterials, Macromolecules, Advanced Drug Delivery Reviews, Journal of Controlled Reslease, Soft Matter, AIChE Journal等重要学术刊物上发表学术论文50余篇，申请中国发明专利21项，美国发明专利3项。现主持国家自然科学基金、生物医用材料北京实验室项目、教育部博士点基金等多项基金。2012年获全国优秀博士学位论文提名奖。

专著：

1. 章莉娟, 林文静, 郭新东, 杨友强, pH响应聚合物胶束药物递送体系设计和构效关系, 科学出版社, 2018年6月。

2. Haripriya Kalluri, Seong-O Choi, Xin Dong Guo, Jeong Woo Lee, James Norman, Mark R. Prausnitz, Evaluation of Microneedles in Human Subjects, Book Chapter in <Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement> edited by Nina Dragicevic and Howard I. Maibach, Springer, 2017, 325-340.

代表性论文：

1. Xuan Jin, Dan Dan Zhu, Bo Zhi Chen, Mohammad Ashfaq, Xin Dong Guo*, Insulin Delivery Systems Combined with Microneedle Technology, Advanced Drug Delivery Reviews, 2018, 127: 119-137.

2. Bo Zhi Chen, Mohammad Ashfaq, Dan Dan Zhu, Xiao Peng Zhang, Xin Dong Guo*, Controlled delivery of insulin using rapidly separating microneedle patches fabricated from genipin-crosslinked Gelatin, Macromolecular Rapid Communication, 2018, 39(20): 1800075.

3. Jia Nan Zhang, Bo Zhi Chen, Mohammad Ashfaq, Xiao Peng Zhang, Xin Dong Guo*, Development of a BDDE-crosslinked hyaluronic acid based microneedles patch as a dermal fillers for anti-ageing treatment, Journal of Industrial and Engineering Chemistry, 2018, 65: 363-369.

4. Juan Li, Yuan Jun Ma, Yan Wang, Bo Zhi Chen, Xin Dong Guo*, Can Yang Zhang*, Dual redox/pH-responsive hybrid polymer-lipid composites: Synthesis, preparation, characterization and application in drug delivery with enhanced therapeutic efficacy, Chemical Engineering Journal, 2018, 341: 450-461.

5. Yang Chen, Bo Zhi Chen, Qi Lei Wang, Xuan Jin, Xin Dong Guo*, Fabrication of polymer coated microneedle patches for transdermal drug delivery, Journal of Controlled Release, 2017, 265: 14-21.

6. Dan Dan Zhu, Qi Lei Wang, Xu Bo Liu, Xin Dong Guo*, Rapidly Separating Microneedles for Transdermal Drug Delivery, Acta Biomaterialia, 2016, 41: 312-319.

7. Qi Lei Wang, Dan Dan Zhu, Xu Bo Liu, Bo Zhi Chen, Xin Dong Guo*, Microneedles with Controlled Bubble Sizes and Drug Distributions for Efficient Transdermal Drug Delivery, Scientific Reports, 2016, 6: 38755.

8. Yan Wang, Qiu Yu Li, Xu Bo Liu, Can Yang Zhang, Zhi Min Wu*, Xin Dong Guo*, Mesoscale simulations and experimental studies of pH-sensitive micelles for controlled drug delivery, ACS Applied Materials & Interfaces, 2015, 7(46): 25592-25600.

9. Shu Yu Nie, Wen Jing Lin, Na Yao, Xin Dong Guo*, Li Juan Zhang*, Drug Release from pH-Sensitive Polymeric Micelles with Different Drug Distributions: Insight from Coarse-Grained Simulations, ACS Applied Materials & Interfaces, 2014, 6(20): 17668-17678.

10. Xin Dong Guo, Nikken Wiradharma, Shao Qiong Liu, Li Juan Zhang, Majad Khan, Yu Qian, Yi-Yan Yang*, Oligomerized alpha-helical KALA peptides with pendant arms bearing cell-adhesion, DNA-binding and endosome-buffering domains as efficient gene transfection vectors, Biomaterials, 2012, 33(26): 6284-6291.

11. Xin Dong Guo, Li Juan Zhang, Zhi Min Wu, Yu Qian*, Dissipative Particle Dynamics Studies on Microstructure of pH-Sensitive Micelles for Sustained Drug Delivery, Macromolecules, 2010, 43(18): 7839-7844.

12. Xin Dong Guo, Li Juan Zhang, Yun Chen, Yu Qian*, Core/Shell pH-Sensitive Micelles Self-Assembled from Cholesterol Conjugated Oligopeptides for Anticancer Drug Delivery, AIChE Journal, 2010, 56(7): 1922-1931.

13. Xin Dong Guo, Jeremy Pang Kern Tan, Sung H. Kim, Li Juan Zhang, Ying Zhang, James L. Hedrick, Yi Yan Yang*, Yu Qian*, Computational studies on self-assembled paclitaxel structures: Templates for hierarchical block copolymer assemblies and sustained drug release, Biomaterials, 2009, 30(33): 6556-6563.

14. Xin Dong Guo, Fanny Tandiono, Nikken Wiradharma, Dingyue Knor, Chuan Guan Tan, Majad Khan, Yu Qian, Yi Yan Yang*, Cationic micelles self-assembled from cholesterol-conjugated oligopeptides as an efficient gene delivery vector, Biomaterials, 2008, 29(36): 4838-4846.

15. Xin Dong Guo, Li Juan Zhang, Yu Qian, Jian Zhou, Effect of composition on the formation of poly(DL-lactide) microspheres for drug delivery systems: Mesoscale simulations, Chemical Engineering Journal, 2007, 131(1-3): 195-201.