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分类:导师信息 来源:中国半岛真人体育 2017-04-12 相关院校:江南大学
性别:男
出生年月:1979年5月4日
职称、职务:教授
电话:
电子邮箱:fujita@jiangnan.edu.cn
【学术简介】
教育背景:
2004-2006日本筑波大学生命環境科学研究科获博士学位
2002-2004日本筑波大学生命環境科学研究科获硕士学位
1998-2002日本筑波大学第二学群生物資源学類获学士学位
工作经历:
2014-现在江南大学生物工程学院教授
2012-2014日本大阪大学微生物病研究所助理教授
2008-2012日本大阪大学微生物病研究所特任助理教授
2007-2008日本大阪大学微生物病研究所博士后
2006-2007瑞士日内瓦大学生物化学学院博士后
2006-2006日本产业技术综合研究所糖锁研究中心博士后
【研究领域】
多年来,藤田盛久博士致力于细胞分子生物学和生物化学的研究,尤其是糖生物学和分子遗传学领域。特别是他在蛋白质糖脂翻译后修饰术语也叫做GPI锚定化的生理功能研究中的突出贡献。他鉴定出并分析了GPI锚结构重构中的关键基因。目前,他把目标放在具有生物学和医学意义的重要糖蛋白胞内转运过程的研究。为了深入了解该过程,运用遗传学方法,细胞生物学和生物化学等技术综合的在动物细胞和酵母细胞中开展研究。
【主要论著】(著作和论文)
OriginalPapers
1.Theiler,R.,Fujita,M.,Nagae,M.,Yamaguchi,Y.,Maeda,Y.,andKinoshita,T.:
Theα-HelicalRegioninp24γ2Subunitofp24ProteinCargoReceptorIsPivotalfortheRecognitionandTransportofGlycosylphosphatidylinositol-anchoredProteins.
J.Biol.Chem.,289:16835-16843(2014)
2.Hirata,T.,Fujita,M.,Kanazawa,N.,Murakami,Y.,Maeda,Y.,andKinoshita,T.:
GlycosylphosphatidylinositolmannosyltransferaseIIistherate-limitingenzymeinglycosylphosphatidylinositolbiosynthesisunderlimiteddolichol-phosphatemannoseavailability.
J.Biochem.,154:257-264(2013)
3.Kanzawa,N.,Shimozawa,N.,Wanders,R.J.,Ikeda,K.,Murakami,Y.,Waterham,H.R.,Mukai,S.,Fujita,M.,Maeda,Y.,Taguchi,R.,Fujiki,Y.,andKinoshita,T.:
DefectivelipidremodelingofGPIanchorsinperoxisomaldisorders,Zellwegersyndrome,andrhizomelicchondrodysplasiapunctata.
J.LipidRes.,53:653-663(2012)
4.Fujita,M.,Watanabe,R.,Jaensch,N.,Romanova-Michaelides,M.,Satoh,T.,Kato,M.,Riezman,H.,Yamaguchi,Y.,Maeda,Y.,andKinoshita,T.:
SortingofGPI-anchoredproteinsintoERexitsitesbyp24proteinsisdependentonremodeledGPI.,
J.CellBiol.,194:61-75(2011)
5.Nakano,Y.,Fujita,M.,Ogino,K.,Kinoshita,T.,Oda,Y.,andHirata,H.:
BiogenesisofGPI-anchoredproteinsisessentialforsurfaceexpressionofsodiumchannelsinzebrafishRohon-Beardneuronstorespondtomechanosensorystimulation.,
Development,137:1689-1698 (2010)
6.Adachi,A.,Kano,F.,Tsuboi,T.,Fujita,M.,Maeda,Y.,andMurata,M.:
Golgi-associatedGSK3{beta}regulatesthesortingprocessofpost-Golgimembranetrafficking.,
J.CellSci.,123:3215-3225 (2010)
7.Fujita,M.,Maeda,Y.,Ra,M.,Yamaguchi,Y.,Taguchi,R.,andKinoshita,T.:
GPIglycanremodelingbyPGAP5regulatestransportofGPI-anchoredproteinsfromtheendoplasmicreticulumtotheGolgi.,
Cell,139:352-365(2009)
8.Hirayama,H.,Fujita,M.,Yoko-o,Y.,andJigami,Y.:
O-mannosylationisrequiredfordegradationoftheendoplasmicreticulum-associateddegradationsubstrateGas1*pviatheubiquitin/proteasomepathwayinSaccharomycescerevisiae.,
J.Biochem.,143(4):555-67(2008)
9.Umemura,M.,Fujita,M.,Yoko-o,Y.,Fukamizu,A.,andJigami,Y.:
SaccharomycescerevisiaeCWH43isinvolvedintheremodelingofthelipidmoietyofGPIanchorstoceramides.,
Mol.Biol.Cell,18(11):4304-16(2007)
10.Maeda,Y.,Tashima,Y.,Houjou,T.,Fujita,M.,Yoko-o,T.,Jigami,Y.,Taguchi,R.,andKinoshita,T.:
FattyacidremodelingofGPI-anchoredproteinsisrequiredfortheirraftassociation.,
Mol.Biol.Cell,18(4):1497-506(2007)
11.Fujita,M.,Umemura,M.,Yoko-o,T.,andJigami,Y.:
PER1isrequiredforGPI-phospholipaseA2activityandinvolvedinlipidremodelingofGPI-anchoredproteins.,
Mol.Biol.Cell,17(12):5253-64(2006)
12.Fujita,M.,Yoko-o,T.,andJigami,Y.:
InositoldeacylationbyBst1pisrequiredforthequalitycontrolofglycosylphosphatidylinositol-anchoredproteins.,
Mol.Biol.Cell,17(2):834-50(2006)
13.Fujita,M.,Yoko-o,T.,Okamoto,M.,andJigami,Y.:
GPI7involvedinglycosylphosphatidylinositolbiosynthesisisessentialforyeastcellseparation.,
J.Biol.Chem.,279(50):51869-79(2004)
ReviewsandBooks
1.Kinoshita,T.,Maeda,Y.andFujita,M.:
Transportofglycosylphosphatidylinositol-anchoredproteinsfromtheendoplasmicreticulum.
Biochim.Biophys.Acta–Mol.CellRes.,inpress(2013)
2.Fujita,M.:
PotentialRolesofGPI-AnchorRemodelinginProteinTraffickingandRaftAssociationinMammalianCells,
TrendsGlycosci.Glycotech.,24:244-257(2012)
3.Fujita,M.*andKinoshita,T.(*correspondingauthor):
GPI-anchorremodeling:PotentialfunctionsofGPI-anchorsinintracellulartraffickingandmembranedynamics.,
Biochim.Biophys.Acta,1821(8):1050-1058(2012)
4.Fujita,M.andKinoshita,T.:
StructuralremodelingofGPIanchorsduringbiosynthesisandafterattachmenttoproteins.,
FEBSLett.,584(9):1670-1677(2010)
5.Maeda,Y.,Fujita,M.,andKinoshita,T.:
GPI-Anchor:UpdateforBiosynthesisandRemodeling,
TrendsGlycosci.Glycotech.,22:182-193(2010)
6.Kinoshita,T.andFujita,M.:
OverviewofGPIbiosynthesis,
TheEnzymes,AcademicPress,26:1-30(2009)
7.Kinoshita,T.,Fujita,M.,andMaeda,Y.:
Biosynthesis,remodellingandfunctionsofmammalianGPI-anchoredproteins:recentprogress.,
J.Biochem.,144(3):287-94(2008)
8.Fujita,M.andJigami,Y.:
LipidremodelingofGPI-anchoredproteinsanditsfunction.,
Biochim.Biophys.Acta,1780(3):410-20(2008)
【科研项目】
2014年江苏省自然科学基金青年基金
【科研成果及奖励】
【荣誉与奖励】
2012 YoungInvestigatorAwardofTheJapaneseBiochemicalSociety
2012 YoungInvestigatorAwardofTheJapaneseSocietyofCarbohydrateResearch
【在读硕、博士人数】
硕士3名
【已毕业硕、博士人数】
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