中国药科大学

李泰明,女，博士，副教授，生物制药教研室主任,药大工作24年,日本进修1年。承担多项国家课题，获得国家、省级奖励多项。发表文章:60多篇，专利10多项，出版教材多本。

①本人研究方向：

1.对糖尿病及其并发症有治疗作用的功能肽研究及新型肽疫苗设计。

2.基因工程技术构建融合蛋白药物及其发酵分离纯化质量控制研究。

②研究成果

代表文章

1.Taiming Li1*(通讯作者). Enhanced antitumor efficacy by combination treatment with a human umbilical vein endothelial cell vaccine and a tumor cell lysate-based vaccine。Tumour Biol. 2013 Oct;34(5):3173-82. SCI

2．Taiming Li*(通讯作者)Improved efficacy of therapeutic vaccination with viable human umbilical vein endothelial cells against murine melanoma by introduction of OK432 as adjuvant.Tumour Biol. 2013 Jun;34(3):1399-408. SCI

3. Taiming L. *(通讯作者)Generation of a Chimeric Plasmin-Resistant Vegf165/Vegf183 (132-158) Protein and its Comparative Activity. Protein Pept Lett. 2013 Aug;20(8):947-54.

4.Taiming Li1*(通讯作者).Immunization with P277 induces vascular leak syndrome in C57BL/6 mice via endothelial damage。Autoimmunity 2010, 43(8)8:654-663 SCI
5.Taiming Li1*(通讯作者).Specific Antibodies Elicited by a Novel DNA Vaccine Targeting Gastrin-Releasing Peptide Inhibit Murine Melanoma Growth In Vivo. American Society for Microbiology. 。Clinical and Vaccine Immunology, 2009,16(7): 1033–1039 SCI

6.Taiming Li1*(通讯作者).Nasal immunization with heat shock protein 65 attenuates atherosclerosis and reduces serum lipids in cholesterol-fed wild-type rabbits probably through different mechanisms. Immunology Letters 2009, 125:40–45 SCI

7.Taiming Li1*(通讯作者).Construction, Expression, Purification and Immunology Effect of an Anti-Atherosclerosis Chimeric Enzyme Vaccine in Escherichia coli。Immunology Letters 2009, 125:40–4。P rotein & Peptide Letters，2008, 15：7 SCI

8.Taiming Li*(通讯作者).Study on preparation and unique properties of a novel insulin analogue with N-terminal Arg-4, Pro-3, Lys-2, Pro-1extension at insulin B-chain。Regulatory Peptides. 2009,157(1-3). SCI

9.Taiming Li*(通讯作者)Quantification of recombinant human relaxin-2 (B-29/A-24) in non-pregnant rat plasma using ultra performance liquid chromatography-mass spectrometry Anal. Methods, 2014,SCI

10.李泰明（第一作者）Cloning, expressing of exendin-4 analogue and bioactivity analysis in vivo. Sheng Wu Gong Cheng Xue Bao. 2012 Jul;28(7):877-86

12. 李泰明（通讯作者）Protective antitumor immunity induced by tumor cell lysates conjugated with。diphtheria toxin and adjuvant epitope in mouse breast tumor model. Chinese Journal of Cancer，2012; 31(6),295-305